Edible and Herbal Plants for the Prevention and Management of COVID-19

Li, Sha; Cheng, Chien-Shan; Zhang, Cheng; Tang, Guo‐Yi; Tan, Hor‐Yue; Chen, Haiyong; Wang, Ning; Lai, Agnes Yuen Kwan; Feng, Yibin

doi:10.3389/fphar.2021.656103

Cited by 24 publications

(24 citation statements)

References 97 publications

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“…Although several repurposed drugs are currently being used for the treatment of COVID-19 patients, they have limited efficacy. Herbal medicines or medicines derived from herbal extracts offer a safer alternative therapy due to their prolonged human use, acceptability with lesser side effects ( Matveeva et al, 2020 ; Jan et al, 2021 ; Li et al, 2021 ). Recently, Chinese traditional medicine has gained popularity due to its antiviral efficacy in in vitro and animal models of SARS-CoV2 ( Ling, 2020 ; Xiong et al, 2020 ; Yang et al, 2020 ; Jan et al, 2021 ; Lee et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…For example, intranasal corticosteroid spray for the recovery of the sense of smell is under clinical trials for COVID-19 patients ( Abdelalim et al, 2021 ). Since pharmaceutical drugs may have many off-target effects, therapeutics based on herbal extracts have recently gained much attention ( Matveeva et al, 2020 ; De Pellegrin et al, 2021 ; Jan et al, 2021 ; Li et al, 2021 ). Here, we evaluated the efficacy of two ayurvedic intranasal (herbal) oil formulations, Anu oil and til tailya ( Duraipandi and Selvakumar, 2020 ), in hamster SARS-CoV2 challenge model.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Prophylactic Use of Intranasal Oil Formulations in the Hamster Model of COVID-19

et al. 2021

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection initiates with viral entry in the upper respiratory tract, leading to coronavirus disease 2019 (COVID-19). Severe COVID-19 is characterized by pulmonary pathologies associated with respiratory failure. Thus, therapeutics aimed at inhibiting the entry of the virus or its internalization in the upper respiratory tract are of interest. Herein, we report the prophylactic application of two intranasal formulations provided by the National Medicinal Plant Board (NMPB), Anu oil and til tailya, in the hamster model of SARS-CoV-2 infection. Prophylactic intra-nasal instillation of these oil formulations exhibited reduced viral load in lungs and resulted in reduced body weight loss and lung-pneumonitis. In line with reduced viral load, histopathological analysis revealed a reduction in lung pathology in the Anu oil group as compared to the control infected group. However, the til tailya group did not show a significant reduction in lung pathology. Furthermore, molecular analysis using mRNA expression profiling indicated reduced expression of pro-inflammatory cytokine genes, including Th1 and Th17 cytokines for both the intranasal formulations as a result of decreased viral load. Together, the prophylactic intranasal application of Anu oil seems to be useful in limiting both viral load and severity in SARS-CoV2 infection in the hamster model.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Prophylactic Use of Intranasal Oil Formulations in the Hamster Model of COVID-19

et al. 2021

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“…Based on the menus of participants who did not become ill and a review of the literature regarding dietary recommendations to reduce risk of contracting COVID-19, we recommend moderate daily physical activity, maintenance of normal body weight, and consumption of the appropriate amounts of red and green peppers, broccoli, onions, garlic, carrots, tomatoes, cauliflower, sauerkraut, oranges, grapefruits, apples, plums, buckwheat groats, oatmeal, whole meal bread, yoghurt, curdled milk, nuts, seeds, pulses, ginger, fish, lean meat, poultry, eggs, olive and rapeseed oil, bee products, drinking mineral water, green tea, as well as cod liver oil as a source of vitamin D, and omega 3 fatty acids. [32,[93][94][95][96][97].…”

Section: Healthy Lifestyle Recommendationmentioning

confidence: 99%

Associations of Nutritional Behavior and Gut Microbiota with the Risk of COVID-19 in Healthy Young Adults in Poland

et al. 2022

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The numerous consequences of the coronavirus disease 2019 (COVID-19) pandemic in healthy young people and the lack of clarity as to the long-term disease outcomes have spurred the search for risk factors for SARS-CoV-2 infection. We aimed to evaluate the associations of nutritional behaviors, gut microbiota, and physical activity with the risk of COVID-19 in healthy young nonobese people. Data on body composition, anthropometric measurements, physical activity, dietary intake, and gut microbiota were obtained from 95 adults (mean age, 34.66 ± 5.76 years). A balanced diet rich in vegetables and fruit, including nuts, wholegrain cereal products, and legumes, covers the need for vitamins and minerals. Such a diet can be an effective measure to reduce the risk of COVID-19 in nonobese healthy physically active young people with normal immune function. People with balanced diet and an average daily consumption of >500 g of vegetables and fruit and >10 g of nuts had an 86% lower risk of COVID-19 compared with those whose diet was not balanced and who consumed lower amounts of these products. It is well documented that proper nutrition, physical activity, and maintenance of normal weight facilitate good health by ensuring optimal immune function. The beneficial effects of these interventions should be strongly emphasized during the COVID-19 pandemic.

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“…Cereal whole grains are crucial for human health because they provide considerable amounts of energy, minerals, and dietary fibre [1,2]. Numerous prospective studies show that eating whole grains regularly reduces the risk of heart disease and diabetes by 20%-30% [3], improves blood glucose regulation [4], improves weight management over time [5], and lowers the risk of some forms of cancer [5]. Multiple national dietary guidelines reflect a critical assessment of the body of data, advising people to eat more "grain items, particularly whole grain cereals", and to consume less processed grains.…”

Section: Introductionmentioning

confidence: 99%

Sorghum: Nutritional Factors, Bioactive Compounds, Pharmaceutical and Application in Food Systems: A Review

Mohamed¹,

Fawzi²,

Basıt³

et al. 2022

Phyton

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After wheat, rice, maize, and barley, sorghum is the fifth most widely grown cereal on the planet. Due to its high production, drought resistance, and heat tolerance, this crop is replacing maize in some areas. Sorghum is available in a variety of colors, including cream, lemon-yellow, red, and even black. The principal grain anatomical components are pericarp, germ or embryo and endosperm. This review provides an overview of key sorghum grain components, including starches, fiber, proteins, lipids, and vitamins. Also, we summarized phenolic compounds, flavonoids, tannins, carotenoids, vitamin E, amines, Policosanols and Phytosterols in sorghum grains. Sorghum is used to manufacture bread and porridge, and it provides a significant source of energy and nutrition for humans; sorghum is extensively farmed for animal feed. However, because the natural components in sorghum are useful in the development of healthy and functional foods, sorghum farming for both biofuel production and human consumption is gaining popularity. Pigmented sorghum grain is high in antioxidants such as polyphenols, primarily tannins, which have a variety of health benefits, including antiproliferative properties linked to the prevention of certain cancers, antioxidant activities linked to the prevention of diseases linked to oxidative stress, and anti-inflammatory effects, as well as improving glucose metabolism. Because these chemicals cannot be assimilated, their application in the food business has been limited, as sorghum is regarded as a lownutritional grain due to the presence of anti-nutritional components such as strong tannins, which form complexes with proteins and iron, limiting their digestibility. This review aims to show the utilization of sorghum as a source of bioactive chemicals and the value they bestow on human health due to the general biological potential it possesses.

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Edible and Herbal Plants for the Prevention and Management of COVID-19

Cited by 24 publications

References 97 publications

Effect of Prophylactic Use of Intranasal Oil Formulations in the Hamster Model of COVID-19

Effect of Prophylactic Use of Intranasal Oil Formulations in the Hamster Model of COVID-19

Associations of Nutritional Behavior and Gut Microbiota with the Risk of COVID-19 in Healthy Young Adults in Poland

Sorghum: Nutritional Factors, Bioactive Compounds, Pharmaceutical and Application in Food Systems: A Review

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