Edible
            <i>Osmanthus fragrans</i>
            flowers: aroma and functional components, beneficial functions, and applications

Yang, Jiani; Gu, Tao; Lu, Yuqin; Xu, Yongqing; Gan, Ren‐You; Ng, Siew Bee; Sun, Quancai; Ye, Peng

doi:10.1080/10408398.2023.2220130

Cited by 4 publications

(3 citation statements)

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“…Over 5000 flavonoids have been identified in plants, recognized as a significant group of natural substances with substantial bioactive potential [ 46 ]. Flavonoids have been shown to inhibit preadipocyte differentiation and reduce lipid accumulation in 3T3-L1 adipocytes [ 27 ]. Isorhamnetin interventions in high-fat diet (HFD)-fed mice can attenuate weight gain and improve lipid accumulation by decreasing the expression of lipogenic genes in white adipose tissue [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…These nutrients exhibit hypolipidemic, anti-diabetic, antiaging, antioxidant, anti-cancer, anti-inflammatory, hepatoprotective activity and immunostimulatory properties [ 23 , 24 , 25 ]. O. fragrans is widely used in the cosmetic industry [ 26 , 27 ]. Osmanthus essential oil is one of the ingredients in many high-end perfumes in Europe [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

“…Osmanthus essential oil is one of the ingredients in many high-end perfumes in Europe [ 28 ]. Cosmetic products with O. fragrans extract have whitening and brightening effects, increased resistance to oxidative damage, and inhibition of melanin formation and tyrosinase activity [ 27 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Osmanthus fragrans Flavonoid Extract Inhibits Adipogenesis and Induces Beiging in 3T3-L1 Adipocytes

Yang,

Lu,

et al. 2024

Foods

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Osmanthus fragrans has a long history of cultivation in Asia and is widely used in food production for its unique aroma, which has important cultural and economic values. It is rich in flavonoids with diverse pharmacological properties, such as antioxidant, anti-tumor, and anti-lipid activities. However, little is known regarding the effects of Osmanthus fragrans flavonoid extract (OFFE) on adipogenesis and pre-adipocyte transdifferentiation. Herein, this research aimed to investigate the effect of OFFE on the differentiation, adipogenesis, and beiging of 3T3-L1 adipocytes and to elucidate the underlying mechanism. Results showed that OFFE inhibited adipogenesis, reduced intracellular reactive oxygen species levels in mature adipocytes, and promoted mitochondrial biogenesis as well as beiging/browning in 3T3-L1 adipocytes. This effect was accompanied by increased mRNA and protein levels of the brown adipose-specific marker gene Pgc-1a, and the upregulation of the expression of UCP1, Cox7A1, and Cox8B. Moreover, the research observed a dose-dependent reduction in the mRNA expression of adipogenic genes (C/EBPα, GLUT-4, SREBP-1C, and FASN) with increasing concentrations of OFFE. Additionally, OFFE activated the AMPK signaling pathway to inhibit adipogenesis. These findings elucidate that OFFE has an inhibitory effect on adipogenesis and promotes browning in 3T3-L1 adipocytes, which lays the foundation for further investigation of the lipid-lowering mechanism of OFFE in vivo in the future.

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Section: Discussionmentioning

confidence: 99%