Edible solid lipid nanoparticles (SLN) as carrier system for antioxidants of different lipophilicity

Abstract

Ferulic acid (FA) and tocopherol (Toc) loaded solid lipid nanoparticles (SLN) were prepared by a hot homogenisation method. The particle size distribution, zeta potential and melting behaviour of the SLN as well as the stability, encapsulation efficiency and radical scavenging activity of FA and Toc in the SLN were analysed. The different formulations containing up to 2.8 mg g−1 of FA or Toc were stable during at least 15 weeks of storage at room temperature. Despite partial degradation and / or release of FA and Toc during storage, significant radical scavenging activity was maintained. DSC measurements and radical scavenging tests after different time periods revealed that the re-structuring of the lipid matrix was connected to the enhanced antioxidant activity of Toc but did not affect the activity of FA.

Lipid nanoparticles (SLN & NLC) for delivery of vitamin E: a comprehensive review

“…The inclusion of VE led to the broadening of the melting range, which is in agreement with the other results. These findings and the time‐dependent changes of the radical scavenging activities of VE‐SLNs make authors think that variations in the location of VE inside the particle occurred . The different behaviour described here could be related to the nature of the systems, which differ in the solid lipid and the surfactant.…”

“…The particles prepared by these authors with −32 mV were stable for 3 weeks. Other lipid particles containing vitamin E with zeta potential around −30 mV have shown different stabilities: 15 weeks at room temperature or 4 weeks at 4°C . This confirms that zeta potential is not the only factor that determines the physical stability of lipid nanoparticles.…”

“…After 15 weeks, the activity fell to 68.2 ± 6.5%. A final study conducted by the same authors demonstrated, by means of electron paramagnetic resonance spectroscopy, that the radical scavenging activity of encapsulated VE was completely retained during 15 weeks .…”

“…Another study was reported by Oehlke et al . , who observed that the initial recovery of VE was 77.4 ± 6.7%. They attributed this loss to the high temperature during particle preparation.…”

“…Another study, made by Oehlke et al . reported that the inclusion of vitamin E in the particles did not interfere with the crystallization of the solid lipid. It was not possible for them to define which polymorphs were formed after particle solidification.…”