Edinburgh primary care depression study: treatment outcome, patient satisfaction, and cost after 16 weeks.

Scott, Allan; Freeman, Chris

doi:10.1136/bmj.304.6831.883

Cited by 176 publications

(124 citation statements)

References 19 publications

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“…For depression studies, 21 studies were included [7,[48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] with 1,095 patients randomized to medication and 932 patients randomized to therapy. Forest plots of posttreatment CBT minus medication effect sizes are shown in Figures 2 and 3 for anxiety and depression, respectively.…”

Section: Resultsmentioning

confidence: 99%

Relative effects of CBT and pharmacotherapy in depression versus anxiety: is medication somewhat better for depression, and CBT somewhat better for anxiety?

et al. 2011

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Background: Little is known about whether cognitive behavioral therapy (CBT) or pharmacotherapy is relatively more advantageous for depressive versus anxiety disorders. Methods: We conducted a meta-analysis wherein we searched electronic databases and references to select randomized controlled studies comparing CBT and pharmacotherapy, with or without placebo, in adults with major depressive or anxiety disorders. The primary effect size was calculated from disorder-specific outcome measures as the difference between CBT and pharmacotherapy outcomes (i.e., positive effect size favors CBT; negative effect size favors pharmacotherapy). Results: Twenty-one anxiety (N 5 1,266) and twenty-one depression (N 5 2,027) studies comparing medication to CBT were included. Including all anxiety disorders, the overall effect size was .25 (95% CI: À0.02, 0.55, P 5.07). Effects for panic disorder significantly favored CBT over medications (.50, 95% CI: 0.02, 0.98). Obsessive-compulsive disorder showed similar effects-sizes, though not statistically significant (.49, 95% CI: À0.11, 1.09). Medications showed a nonsignificant advantage for social anxiety disorder (À.22, 95% CI: À0.50, 0.06). The overall effect size for depression studies was .05 (95% CI: À0.09, 0.19), with no advantage for medications or CBT. Pooling anxiety disorder and depression studies, the omnibus comparison of the relative difference between anxiety and depression in effectiveness for CBT versus pharmacotherapy pointed to a nonsignificant advantage for CBT in anxiety versus depression (B 5 .14, 95% CI: À0.14, 0.43). Conclusions: On balance, the evidence presented here indicates that there are at most very modest differences in effects of CBT versus pharmacotherapy in the treatment of anxiety versus depressive disorders. There seems to be larger differences between the anxiety disorders in terms of their relative responsiveness to pharmacotherapy versus CBT. Depression and Anxiety 28:560-567, 2011.

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Section: Resultsmentioning

confidence: 99%

Relative effects of CBT and pharmacotherapy in depression versus anxiety: is medication somewhat better for depression, and CBT somewhat better for anxiety?

et al. 2011

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“…[15][16][17][18][19][20][21][34][35][36][37][38][39][40][41] In these 15 studies, a total of 1505 patients participated (804 in the psychological treatment conditions and 701 in the control conditions). Selected characteristics of the studies included are presented in Table 1.…”

Section: Description Of Included Studiesmentioning

confidence: 99%

Psychological treatment of depression in primary care: a meta-analysis

Cuijpers

Straten²,

Andersson³

2009

Br J Gen Pract

152

124

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“…In a randomized trial among US urban primary care patients, Schulberg et al (1996) found that manual-based Interpersonal Psychotherapy was clearly superior to Epidemiologia e Psichiatria Sociale, 9, 3, 2000 usual primary care. In the Edinburgh Primary Care Depression Study, clinical improvement during cognitive therapy was similar to that seen in specialty trials (Scott & Freeman, 1992). Mynor-Wallis et al (1995) demonstrated that a structured 6-session problem solving psychotherapy program (provided by either specialists or specially trained general practitioners) was superior to a pillplacebo control treatment.…”

Section: The Effectiveness Of Treatmentmentioning

confidence: 91%