Editor’s Choice Articles for August

Abstract

My first Editor's Choice article is a unique pre-specified secondary analysis of the PEPaNIC (early versus late parenteral nutrition in the pediatric ICU) trial cohort data (1). Over 600 post-PICU patients were assessed at 2 and 4 years after illness. The long-term physical, emotional/behavioral, and neurocognitive developmental findings were compared with over 350 matched healthy children. The question addressed was whether former PICU patients "grow into" or "grow out of " their developmental legacy over time. The data and detailed supplemental digital content are worth studying and considering in the context of outcomes in other PICU clinical trial populations (8). The editorial highlights the potential impact of health disparities and social determinants of health on such post-PICU outcomes (5).