Editorial (Asia-Pacific Health 2020 and Genomics without Borders: Co-Production of Knowledge by Science and Society Partnership for Global Personalized Medicine)

Özdemir, Vural; Muljono, David Handojo; Pang, Tikki; Ferguson, Lynnette R.; Manamperi, A.; Samper, Sofía; Someya, Toshiyuki; Tassé, Anne Marie; Tsai, Shih‐Jen; Zhou, Hong‐Hao; Lee, Edmund J.D.

doi:10.2174/187569211794728841

Cited by 19 publications

(23 citation statements)

References 46 publications

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“…Work on these issues will have to focus not only on inequalities in the promises for rational therapeutics and PMed/PCard existing within subpopu-lations in the developed societies, but also those impacting fair access to healthcare in low- and middle-income countries (LMICs) globally [121]. The challenge for innovation in post-genomic PMed/PCard is markedly much greater in LMICs where basic infrastructures are often under-resourced and anticipated institutional relationships can be fragile [122].…”

Section: Ethical Legal and Social Implications Of Incorporating mentioning

confidence: 99%

Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology

Pasipoularides

2017

International Journal of Cardiology

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For most of Medicine’s past, the best that physicians could do to cope with disease prevention and treatment was based on the expected response of an average patient. Currently, however, a more personalized/precise approach to cardiology and medicine in general is becoming possible, as the cost of sequencing a human genome has declined substantially. As a result, we are witnessing an era of precipitous advances in biomedicine and bourgeoning understanding of the genetic basis of cardiovascular and other diseases, reminiscent of the resurgence of innovations in physico-mathematical sciences and biology-anatomy-cardiology in the Renaissance, a parallel time of radical change and reformation of medical knowledge, education and practice. Now on the horizon is an individualized, diverse patient-centered, approach to medical practice that encompasses the development of new, gene-based diagnostics and preventive medicine tactics, and offers the broadest range of personalized therapies based on pharmacogenetics. Over time, translation of genomic and high-tech approaches unquestionably will transform clinical practice in cardiology and medicine as a whole, with the adoption of new personalized medicine approaches and procedures. Clearly, future prospects far outweigh present accomplishments, which are best viewed as a promising start. It is now essential for pluridisciplinary health care providers to examine the drivers and barriers to the clinical adoption of this emerging revolutionary paradigm, in order to expedite the realization of its potential. So, we are not there yet, but we are definitely on our way.

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Section: Ethical Legal and Social Implications Of Incorporating mentioning

confidence: 99%

Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology

Pasipoularides

2017

International Journal of Cardiology

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“…3 But for big data to have a compelling impact on the recent investments in bioeconomies such as the US, EU, and beyond, both people and technology need to be connected in order to achieve a form of ''collective innovation'' that is more effective than any individual or singular group of people and computers. [3][4][5] This both elevates and challenges the old notions of innovation that tend to rely on ''single scientist, single computer, single project'' models.…”

Section: From Big Data To Innovationmentioning

confidence: 99%

DELSA Global for “Big Data” and the Bioeconomy: Catalyzing Collective Innovation

Kolker

Stewart

Özdemir

2012

Industrial Biotechnology

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“…Because innovation future(s) are ostensibly uncertain in ''sociotechnical systems'' that coproduce scientific knowledge ( Jasanoff, 2006), decision makers ideally should continually monitor a technology in real-time as it coevolves with society, in order to understand the ways in which science-technologysociety are interwoven in the course of an innovation (Ozdemir et al, , 2011b. This provides the stakeholders with the flexibility and resilience to better adapt and promptly respond to whatever consequences might emerge on innovation trajectories.…”

Section: From Forecast To Foresightmentioning

confidence: 99%

“…Such recognition is necessary to steer innovations and emerging technologies in a manner that is closely attuned to social values (Einsiedel, 2011;Gaskell et al, 2005;Lehoux, 2011). Ultimately, this serves to integrate scientific and social knowledge thereby steering innovations to coproduce results and outputs that are socially robust and context sensitive (Ozdemir et al, 2010(Ozdemir et al, , 2011b.…”

Section: Future Promises and Caveatsmentioning

confidence: 99%

“…It also requires new ways of governance of science, knowledge production, and management (Bell and Hindmoor, 2009;Carlile, 2004;Cook and Brown, 1999;Faraj and Yan, 2009;Huzair et al, 2011;Ozdemir et al, 2010Ozdemir et al, , 2011a. It demands an understanding of the ways in which science-technology-society are interwoven in coproduction of knowledge on a day-to-day basis (Bijker et al, 1987;Faraj et al, 2004;Jasanoff, 2006;Ozdemir et al, 2011b;Ravetz, 1971;Yearley, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Steering Vaccinomics Innovations with Anticipatory Governance and Participatory Foresight

Özdemir

Faraj

Knoppers

2011

OMICS: A Journal of Integrative Biology

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Vaccinomics is the convergence of vaccinology and population-based omics sciences. The success of knowledge-based innovations such as vaccinomics is not only contingent on access to new biotechnologies. It also requires new ways of governance of science, knowledge production, and management. This article presents a conceptual analysis of the anticipatory and adaptive approaches that are crucial for the responsible design and sustainable transition of vaccinomics to public health practice. Anticipatory governance is a new approach to manage the uncertainties embedded on an innovation trajectory with participatory foresight, in order to devise governance instruments for collective "steering" of science and technology. As a contrast to hitherto narrowly framed "downstream impact assessments" for emerging technologies, anticipatory governance adopts a broader and interventionist approach that recognizes the social construction of technology design and innovation. It includes in its process explicit mechanisms to understand the factors upstream to the innovation trajectory such as deliberation and cocultivation of the aims, motives, funding, design, and direction of science and technology, both by experts and publics. This upstream shift from a consumer "product uptake" focus to "participatory technology design" on the innovation trajectory is an appropriately radical and necessary departure in the field of technology assessment, especially given that considerable public funds are dedicated to innovations. Recent examples of demands by research funding agencies to anticipate the broad impacts of proposed research--at a very upstream stage at the time of research funding application--suggest that anticipatory governance with foresight may be one way how postgenomics scientific practice might transform in the future toward responsible innovation. Moreover, the present context of knowledge production in vaccinomics is such that policy making for vaccines of the 21st century is occurring in the face of uncertainties where the "facts are uncertain, values in dispute, stakes high and decisions urgent and where no single one of these dimensions can be managed in isolation from the rest." This article concludes, however, that uncertainty is not an accident of the scientific method, but its very substance. Anticipatory governance with participatory foresight offers a mechanism to respond to such inherent sociotechnical uncertainties in the emerging field of vaccinomics by making the coproduction of scientific knowledge by technology and the social systems explicit. Ultimately, this serves to integrate scientific and social knowledge thereby steering innovations to coproduce results and outputs that are socially robust and context sensitive.

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Editorial (Asia-Pacific Health 2020 and Genomics without Borders: Co-Production of Knowledge by Science and Society Partnership for Global Personalized Medicine)

Cited by 19 publications

References 46 publications

Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology

Genomic translational research: Paving the way to individualized cardiac functional analyses and personalized cardiology

DELSA Global for “Big Data” and the Bioeconomy: Catalyzing Collective Innovation

Steering Vaccinomics Innovations with Anticipatory Governance and Participatory Foresight

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