Editorial on the Research Topic Bioinformatics of genome regulation and systems biology, Volume III This Research Topic, "Bioinformatics of genome regulation and systems biology, Volume III," continues the studies in the field of bioinformatics of gene expression presented initially in Frontiers in Genetics journal (https://www.frontiersin.org/research-topics/8383/ bioinformatics-of-genome-regulation-and-systems-biology) and then in the Volumes I and II (Orlov et al, 2021a;Orlov et al, 2021c) (https://www.frontiersin.org/researchtopics/14266/bioinformatics-of-genome-regulation-volume-i). The materials presented in these Research Topics were initially discussed in a BGRS\SB (Bioinformatics of Genome Regulation and Structure\Systems Biology) conference series in Novosibirsk, Russia (https:// bgrssb.icgbio.ru/2022/) (Kolchanov and Orlov, 2013;Orlov et al, 2015), and then complemented by new works on bioinformatics and computational genomics.