Editorial Comment to Morphological effects of mitomycin C on urothelial responses to experimentally‐induced urethral stricture in rats

Mellon, Matthew J.

doi:10.1111/iju.12800

Cited by 1 publication

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References 2 publications

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“…In recent years, MMC has been increasingly used as an adjunctive agent to increase treatment success and reduce recurrence. 102 103 MMC combined with DVIU effectively reduces the long-term recurrence rate of short-segment anterior urethral stricture and increases the success rate of the first urethrotomy in the posterior urethra. 100 104 During DVIU, the existing fibrotic stricture is cut from healthy tissue, and submucosal MMC injections prevent fibroblast infiltration during scar remodeling, significantly reducing the recurrence rate of postoperative stricture.…”

Section: Therapeutic Drugsmentioning

confidence: 98%

Pharmacotherapy of urethral stricture

Luo,

Lou,

Xie

et al. 2023

Asian Journal of Andrology

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Urethral stricture is characterized by the chronic formation of fibrous tissue, leading to the narrowing of the urethral lumen. Despite the availability of various endoscopic treatments, the recurrence of urethral strictures remains a common challenge. Postsurgery pharmacotherapy targeting tissue fibrosis is a promising option for reducing recurrence rates. Although drugs cannot replace surgery, they can be used as adjuvant therapies to improve outcomes. In this regard, many drugs have been proposed based on the mechanisms underlying the pathophysiology of urethral stricture. Ongoing studies have obtained substantial progress in treating urethral strictures, highlighting the potential for improved drug effectiveness through appropriate clinical delivery methods. Therefore, this review summarizes the latest researches on the mechanisms related to the pathophysiology of urethral stricture and the drugs to provide a theoretical basis and new insights for the effective use and future advancements in drug therapy for urethral stricture.

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