Editorial commentary to “18F-Fluorocholine PET uptake correlates with pathologic evidence of recurrent tumor after stereotactic radiosurgery for brain metastases” by Grkovski and colleagues

Lovinfosse, Pierre; Mustapha, Selma Ben; Withofs, Nadia

doi:10.1007/s00259-019-04651-7

Cited by 1 publication

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“…The detection of 11 C-labeled Cho is FDA-approved for positron emission tomography (PET) imaging in suspected recurrent prostate cancer (Medicine S of N, 2012), and this agent and 18 F-labeled Cho variants are being studied for PET imaging in other cancers as well (Talbot et al, 2014;Bolcaen et al, 2015;Radzikowski et al, 2022). While there are concerns of limited tissue-specificity for this application, PET detection of radiolabeled Cho for characterization of tumor lesions in the brain is an area of active research (Calabria et al, 2018;Lovinfosse et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)

Ip¹,

Thomas²,

Behar³

et al. 2023

Front. Cell. Neurosci.

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IntroductionThere is a lack of robust metabolic imaging techniques that can be routinely applied to characterize lesions in patients with brain tumors. Here we explore in an animal model of glioblastoma the feasibility to detect uptake and metabolism of deuterated choline and describe the tumor-to-brain image contrast.MethodsRG2 cells were incubated with choline and the level of intracellular choline and its metabolites measured in cell extracts using high resolution 1H NMR. In rats with orthotopically implanted RG2 tumors deuterium metabolic imaging (DMI) was applied in vivo during, as well as 1 day after, intravenous infusion of 2H9-choline. In parallel experiments, RG2-bearing rats were infused with [1,1′,2,2′-2H4]-choline and tissue metabolite extracts analyzed with high resolution 2H NMR to identify molecule-specific 2H-labeling in choline and its metabolites.ResultsIn vitro experiments indicated high uptake and fast phosphorylation of exogenous choline in RG2 cells. In vivo DMI studies revealed a high signal from the 2H-labeled pool of choline + metabolites (total choline, 2H-tCho) in the tumor lesion but not in normal brain. Quantitative DMI-based metabolic maps of 2H-tCho showed high tumor-to-brain image contrast in maps acquired both during, and 24 h after deuterated choline infusion. High resolution 2H NMR revealed that DMI data acquired during 2H-choline infusion consists of free choline and phosphocholine, while the data acquired 24 h later represent phosphocholine and glycerophosphocholine.DiscussionUptake and metabolism of exogenous choline was high in RG2 tumors compared to normal brain, resulting in high tumor-to-brain image contrast on DMI-based metabolic maps. By varying the timing of DMI data acquisition relative to the start of the deuterated choline infusion, the metabolic maps can be weighted toward detection of choline uptake or choline metabolism. These proof-of-principle experiments highlight the potential of using deuterated choline combined with DMI to metabolically characterize brain tumors.

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Section: Introductionmentioning

confidence: 99%

Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)

Ip¹,

Thomas²,

Behar³

et al. 2023

Front. Cell. Neurosci.

View full text Add to dashboard Cite

show abstract

Editorial commentary to “18F-Fluorocholine PET uptake correlates with pathologic evidence of recurrent tumor after stereotactic radiosurgery for brain metastases” by Grkovski and colleagues

Abstract: Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Cited by 1 publication

References 18 publications

Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)

Mapping of exogenous choline uptake and metabolism in rat glioblastoma using deuterium metabolic imaging (DMI)

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