Editorial: Diagnosing Equine Pars Intermedia Dysfunction: Are We There Yet?

Toribio, Ramiro E.

doi:10.1111/j.1939-1676.2005.tb02674.x

Cited by 8 publications

(6 citation statements)

References 5 publications

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“…Previous advice is that diagnostic testing for PPID should be avoided in the autumn due to seasonal variability in plasma ACTH concentrations and a high risk of false positive diagnoses (Donaldson et al 2005;Toribio 2005). Additionally, it has been suggested that fluctuations in plasma ACTH concentrations could confound the monitoring of horses with PPID and affect assessment of response to dopamine agonist therapy (Beech et al 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, seasonal variation in plasma ACTH concentrations might also affect monitoring of PPID cases and assessment of their response to therapy. Hence, seasonally adjusted reference intervals for plasma ACTH concentrations should be considered to improve the probability of an accurate diagnosis and to facilitate patient monitoring throughout the year (Toribio 2005;Frank et al 2010).…”

Section: Introductionmentioning

confidence: 99%

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Circannual variation in plasma adrenocorticotropic hormone concentrations in the UK in normal horses and ponies, and those with pituitarypars intermediadysfunction

Copas

Durham

2011

Equine Veterinary Journal

100

128

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SummaryReasons for performing study: Pituitary pars intermedia dysfunction (PPID) is a common endocrinopathy, frequently diagnosed via plasma adrenocorticotropic hormone (ACTH) concentrations. Seasonal variation in plasma ACTH concentrations has been described in normal horses prompting caution in diagnosing PPID at certain times of the year. The aims of this study were to determine appropriate reference intervals for equine plasma ACTH throughout the year; and to examine the circannual variation of plasma ACTH concentrations in PPID cases. Hypothesis: Plasma ACTH can be used as a test for PPID throughout the year with the use of appropriate reference intervals. Methods: Data for reference interval calculations were obtained from samples collected from inpatients of Liphook Equine Hospital (non-PPID group, n = 156). Data from PPID cases (n = 941) were obtained from samples submitted to the Liphook Equine Hospital Laboratory from horses with a clinical suspicion of PPID found to have plasma ACTH concentrations greater than our upper reference interval for that time of year. Results: Upper limits for reference interval of plasma ACTH were 29 pg/ml between November and July and 47 pg/ml between August and October. Circannual variation in plasma ACTH occurred in both non-PPID and PPID horses with the highest ACTH concentrations found between August and October in both groups (P<0.0001). The greatest difference between the 2 populations also occurred between August and October. Conclusions: Plasma ACTH can be used for the diagnosis and monitoring of PPID throughout the year with the use of appropriate reference intervals. These findings demonstrate an increase in pituitary gland secretory activity during the late summer and autumn in both normal and PPID cases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Circannual variation in plasma adrenocorticotropic hormone concentrations in the UK in normal horses and ponies, and those with pituitarypars intermediadysfunction

Copas

Durham

2011

Equine Veterinary Journal

100

128

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“…Pituitary pars intermedia dysfunction, commonly referred to as equine Cushing' s syndrome, is the most common endocrinopathy of older horses and ponies. 20 Clinical, pharmacological, biochemical, and histologic data indicate that PPID is a neurodegenerative disease with loss of dopaminergic inhibitory input to the melanotropes of the pars intermedia. 21 Similar to other neurodegenerative diseases, age is the most important risk factor for the development of PPID.…”

mentioning

confidence: 99%

Evaluation of the effects of age and pituitary pars intermedia dysfunction on corneal sensitivity in horses

Miller

Lassaline

Beech

2013

ajvr

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“…A presumptive diagnosis of PPID can be made based on the presence of hypertrichosis in aged horses [ 108 , 109 , 110 , 111 , 112 ]. Laboratory testing is recommended in cases where treatment is financially feasible, where early or severe clinical disease is suspected [ 54 ], or to determine the response to treatment [ 54 ].…”

Section: Diagnosismentioning

confidence: 99%

Pituitary Pars Intermedia Dysfunction (PPID) in Horses

Kirkwood

Hughes

Stewart

2022

Veterinary Sciences

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Substantial morbidity results from pituitary pars intermedia dysfunction (PPID) which is often underestimated by owners and veterinarians. Clinical signs, pathophysiology, diagnostic tests, and treatment protocols of this condition are reviewed. The importance of improved recognition of early clinical signs and diagnosis are highlighted, as initiation of treatment will result in improved quality of life. Future research should be targeted at improving the accuracy of the diagnosis of PPID, as basal adrenocorticotropic hormone (ACTH) concentration can lack sensitivity and thyrotropin releasing hormone (TRH) used to assess ACTH response to TRH stimulation is not commercially available as a sterile registered product in many countries. The relationship between PPID and insulin dysregulation and its association with laminitis, as well as additional management practices and long-term responses to treatment with pergolide also require further investigation.

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Editorial: Diagnosing Equine Pars Intermedia Dysfunction: Are We There Yet?

Cited by 8 publications

References 5 publications

Circannual variation in plasma adrenocorticotropic hormone concentrations in the UK in normal horses and ponies, and those with pituitarypars intermediadysfunction

Circannual variation in plasma adrenocorticotropic hormone concentrations in the UK in normal horses and ponies, and those with pituitarypars intermediadysfunction

Evaluation of the effects of age and pituitary pars intermedia dysfunction on corneal sensitivity in horses

Pituitary Pars Intermedia Dysfunction (PPID) in Horses

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