Editorial: Enhancing frailty assessment in liver transplantation candidates—The role of the Duke Activity Status Index in predicting mortality and guiding prehabilitation

Harris, Sara J.; Stine, Jonathan G.

doi:10.1111/apt.17860

Aliment Pharmacol Ther

2024

DOI: 10.1111/apt.17860

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Editorial: Enhancing frailty assessment in liver transplantation candidates—The role of the Duke Activity Status Index in predicting mortality and guiding prehabilitation

Sara J. Harris,

Jonathan G. Stine

Abstract: LINKED CONTENTThis article is linked to Williams et al papers. To view these articles, visit https://doi.org/10.1111/apt.17834 and https://doi.org/10.1111/apt.17874

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Editorial: Enhancing frailty assessment in liver transplantation candidates—The role of the Duke Activity Status Index (DASI) in predicting mortality and guiding prehabilitation. Authors' reply

Armstrong,

Williams

2024

Aliment Pharmacol Ther

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Editorial: Enhancing frailty assessment in liver transplantation candidates—The role of the Duke Activity Status Index (DASI) in predicting mortality and guiding prehabilitation. Authors' reply

Armstrong,

Williams

2024

Aliment Pharmacol Ther

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Frailty in liver transplantation: Exploring prescribing exercise as medicine to improve patient outcomes

Harris,

Stine

2024

Liver International

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Liver transplantation (LT) represents a curative avenue for individuals with advanced chronic liver disease. Given the inherent illness severity of LT candidates, identifying patients at greater risk for adverse outcomes before and after transplantation is paramount. Approximately 50% of cirrhotic patients are frail and have considerable functional impairment. Various measures have been used to assess frailty, including performance‐based tests and functional status evaluations. Frailty carries significant prognostic implications and predicts both mortality and pre‐ and post‐LT complications. Contributing factors to frailty in this population include sarcopenia, malnutrition, inflammation, and psychosocial factors. Recognizing the prevalence of frailty among LT candidates, exercise interventions have been developed to improve physical frailty and offer potential to improve patient outcomes. While many interventions have demonstrated efficacy without notable adverse events, the absence of a universally accepted standard for exercise prescription underscores the variability in intervention elements and patient adherence. Given the safety profile of exercise interventions, there remains a critical need for standardized protocols and guidelines to optimize exercise regimens for LT candidates. This review delves into the landscape of frailty among LT candidates, elucidating its etiological underpinnings, impact on outcomes, utilization of exercise interventions, and the efficacy of exercise programs in reducing the burden frailty in those awaiting LT.

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Editorial: Enhancing frailty assessment in liver transplantation candidates—The role of the Duke Activity Status Index in predicting mortality and guiding prehabilitation

Abstract: LINKED CONTENTThis article is linked to Williams et al papers. To view these articles, visit https://doi.org/10.1111/apt.17834 and https://doi.org/10.1111/apt.17874

Cited by 2 publications

References 12 publications

Editorial: Enhancing frailty assessment in liver transplantation candidates—The role of the Duke Activity Status Index (DASI) in predicting mortality and guiding prehabilitation. Authors' reply

Editorial: Enhancing frailty assessment in liver transplantation candidates—The role of the Duke Activity Status Index (DASI) in predicting mortality and guiding prehabilitation. Authors' reply

Frailty in liver transplantation: Exploring prescribing exercise as medicine to improve patient outcomes

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