Editorial: Epigenetic Variation Influences on Livestock Production and Disease Traits

Ibeagha‐Awemu, Eveline M.; Kiefer, Hélène; McKay, Stephanie; Liu, George E.

doi:10.3389/fgene.2022.942747

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Epigenetic modifications are considered as one of the potential mechanisms involved in other production and disease traits of cattle. 32 , 33 In this direction, we determined genome-wide DNA methylations in the peripheral blood mononuclear cells (PBMC) of Hariana ( B indicus ) and Vrindavani ( B indicus × B taurus ) cattle breeds. The variance partition analysis of genome-wide methylation distribution showed breed-wise separation and clustering, clearly showing that they have distinct genome-wide DNA methylation profiles.…”

Section: Discussionmentioning

confidence: 93%

Genome-wide DNA methylation profiles regulate distinct heat stress response in zebu (Bos indicus) and crossbred (Bos indicus × Bos taurus) cattle

Sajjanar,

Aalam,

Khan

et al. 2024

Cell Stress and Chaperones

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Section: Discussionmentioning

confidence: 93%

Genome-wide DNA methylation profiles regulate distinct heat stress response in zebu (Bos indicus) and crossbred (Bos indicus × Bos taurus) cattle

Sajjanar,

Aalam,

Khan

et al. 2024

Cell Stress and Chaperones

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“…In farm animal disease management, various effective approaches, such as genome editing ( 50 ), RNA interference ( 51 ), and the selection of animals with genetic traits resistant to diseases ( 52 ), have been used. Moreover, targeting epigenetic markers ( 53 ) and miRNAs ( 54 ) has emerged as promising tools.…”

Section: Micrornas In Farm Animal Diseasesmentioning

confidence: 99%

MicroRNAs: exploring their role in farm animal disease and mycotoxin challenges

Kappari,

Dasireddy,

Applegate

et al. 2024

Front. Vet. Sci.

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MicroRNAs (miRNAs) serve as key regulators in gene expression and play a crucial role in immune responses, holding a significant promise for diagnosing and managing diseases in farm animals. This review article summarizes current research on the role of miRNAs in various farm animal diseases and mycotoxicosis, highlighting their potential as biomarkers and using them for mitigation strategies. Through an extensive literature review, we focused on the impact of miRNAs in the pathogenesis of several farm animal diseases, including viral and bacterial infections and mycotoxicosis. They regulate gene expression by inducing mRNA deadenylation, decay, or translational inhibition, significantly impacting cellular processes and protein synthesis. The research revealed specific miRNAs associated with the diseases; for instance, gga-miR-M4 is crucial in Marek’s disease, and gga-miR-375 tumor-suppressing function in Avian Leukosis. In swine disease such as Porcine Respiratory and Reproductive Syndrome (PRRS) and swine influenza, miRNAs like miR-155 and miR-21-3p emerged as key regulatory factors. Additionally, our review highlighted the interaction between miRNAs and mycotoxins, suggesting miRNAs can be used as a biomarker for mycotoxin exposure. For example, alterations in miRNA expression, such as the dysregulation observed in response to Aflatoxin B1 (AFB1) in chickens, may indicate potential mechanisms for toxin-induced changes in lipid metabolism leading to liver damage. Our findings highlight miRNAs potential for early disease detection and intervention in farm animal disease management, potentially reducing significant economic losses in agriculture. With only a fraction of miRNAs functionally characterized in farm animals, this review underlines more focused research on specific miRNAs altered in distinct diseases, using advanced technologies like CRISPR-Cas9 screening, single-cell sequencing, and integrated multi-omics approaches. Identifying specific miRNA targets offers a novel pathway for early disease detection and the development of mitigation strategies against mycotoxin exposure in farm animals.

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“…They further showed that MTCH2 promotes fat generation in muscles in an m6A-dependent manner [96]. m6A RNA methylation, through the regulation of metabolites by gut microbiota, such as folic acid and butyric acid, affects the nutrition, absorption, and metabolic mechanisms of livestock [97]. ONT sequencing technology is expected to provide targets for precise nutrition and targeted regulation in different livestock.…”

Section: Application Of Tgs In Rna Epigenetic Modificationsmentioning

confidence: 99%

When Livestock Genomes Meet Third-Generation Sequencing Technology: From Opportunities to Applications

Liu,

Zheng,

Ding

et al. 2024

Genes

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Editorial: Epigenetic Variation Influences on Livestock Production and Disease Traits

Cited by 6 publications

References 23 publications

Genome-wide DNA methylation profiles regulate distinct heat stress response in zebu (Bos indicus) and crossbred (Bos indicus × Bos taurus) cattle

Genome-wide DNA methylation profiles regulate distinct heat stress response in zebu (Bos indicus) and crossbred (Bos indicus × Bos taurus) cattle

MicroRNAs: exploring their role in farm animal disease and mycotoxin challenges

When Livestock Genomes Meet Third-Generation Sequencing Technology: From Opportunities to Applications

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