Editorial: Ethnopharmacological Responses to the Coronavirus Disease 2019 Pandemic

Wang, Jiabo; Andrade‐Cetto, Adolfo; Echeverría, Javier; Wardle, Jon; Yen, Hung-Rong; Heinrich, Michael

doi:10.3389/fphar.2021.798674

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…With fewer resources to contain the spread of COVID-19 in Africa, the potential for new variants and endemicity, and underlying support for integration, there is a strong case for enhanced R&D of ATMs-derived herbal medicines for the prophylactic and therapeutic management of the disease, particularly as a complementary treatment measure 13 14. The results of early scientific examination suggest, for example, that traditional medicines from ATMs and other traditions can be effective as adjuvant symptomatic treatment for some clinical manifestations of COVID-19 26. Reverse pharmacology approach to investigate medicinal plants used in ATMs with putative anti-viral properties could serve to identify new preventive and therapeutic agents for inhibition of SARS-CoV-2 and the treatment of COVID-19.…”

Section: Atm-based Therapies In the Management Of Covid-19 In Africamentioning

confidence: 99%

“…Despite the abundant natural resources and the anecdotal value of traditional medicine, ATMs remains under-represented and underused in conventional health settings in Africa,26 as demonstrated during the pandemic. While there are several reasons for this,11 37 in the course of the COVID-19 pandemic, the challenges observed include widely publicised unsubstantiated claims of therapeutic activity, insufficient preclinical data, lack of clinical data to validate ethnobotanical claims and insufficient regulatory oversight 38.…”

Section: Benefits and Challenges Associated With The Use Of Atmsmentioning

confidence: 99%

“…13 14 The results of early scientific examination suggest, for example, that traditional medicines from ATMs and other traditions can be effective as adjuvant symptomatic treatment for some clinical manifestations of COVID-19. 26 Reverse pharmacology approach to investigate medicinal plants used in ATMs with putative anti-viral properties could serve to identify new preventive and therapeutic agents for inhibition of SARS-CoV-2 and the treatment of COVID-19. Ethnopharmacological evidence highlights the extensive use of specific medicinal plants for COVID-19-like symptoms by certain ethnic groups in Africa, which may assist with identifying candidate medicinal plants or plant recipes for further R&D. 27 Results may have regional or even global significance, as there is anecdotal evidence suggesting that some traditional medicines are effective across various diseases and sociocultural contexts.…”

Section: Atm-based Therapies In the Management Of Covid-19 In Africamentioning

confidence: 99%

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Experiences and challenges of African traditional medicine: lessons from COVID-19 pandemic

Mutombo,

Kasilo,

James

et al. 2023

BMJ Glob Health

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Management of COVID-19 in Africa is challenging due to limited resources, including the high cost of vaccines, diagnostics, medical devices and routine pharmaceuticals. These challenges, in addition to wide acceptability, have resulted in increased use of herbal medicines based on African traditional medicines (ATMs) by patients in Africa. This is in spite of the often-significant gaps in evidence regarding these traditional medicines as to their efficacy and safety for COVID-19. African scientists, with some support from their governments, and guidance from WHO and other bodies, are addressing this evidence gap, developing and testing herbal medicines based on ATMs to manage mild-to-moderate cases of COVID-19. Such efforts need further support to meet public health needs.

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Section: Atm-based Therapies In the Management Of Covid-19 In Africamentioning

confidence: 99%

Section: Benefits and Challenges Associated With The Use Of Atmsmentioning

confidence: 99%

Section: Atm-based Therapies In the Management Of Covid-19 In Africamentioning

confidence: 99%

See 1 more Smart Citation

Experiences and challenges of African traditional medicine: lessons from COVID-19 pandemic

Mutombo,

Kasilo,

James

et al. 2023

BMJ Glob Health

Self Cite

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“…An editorial by (Wang et al, 2021) in this journal commented on the research topic "ethnopharmacological responses to the corona virus disease", illustrating the enormous potential of treatment options for this health problem from traditional medicine systems, but also pointing out the challenges faced by research in this context.…”

Section: Introductionmentioning

confidence: 99%

Historical texts as a potential resource for plant-derived natural products against SARS-CoV-2 – the example of theReceptariumof Burkhard III von Hallwyl from 16th century Switzerland

Vahekeni,

Stehlin,

Urmann

et al. 2024

Preprint

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In the search for more effective prophylactic and possibly curative therapeutics against SARS-CoV-2, an historical-ethnobotanical approach was used to select plants described in theReceptariumof Burkhard III von Hallwyl (RBH), an influential recipe text from 16th century Switzerland. Ten species were identified based on specific historical uses presumably linked with the treatment of viral infections as well as inflammatory conditions. For each plant candidate, aqueous and hydroethanolic extracts have been produced. CellTiter-Glo® Luminescent Cell Viability Assay was used to assess antiviral activity against SARS-CoV-2 and the effect on cell viability of the extracts.Of the ten plant species tested, four displayed an antiviral activity ≥ 50% at 16.7 µg/ml with acceptable cell viability (> 75%):Sambucus nigraL. (leaves),Viola odorataL. (leaves),Geranium robertianumL. (arial parts) andArtemisia vulgarisL. (aerial parts). The crude extracts were partitioned in aqueous and organic fractions and further analyzed. The ethyl acetate fractions ofS. nigra, V. odorataandG. robertianumexpressed significant antiviral activity of nearly 100% at 5.6 µg/ml (P < 0.05). The most potent inhibitory activity was observed for the ethyl acetate fraction ofViola odorataL. (leaves) with 87% at 1.9 µg/ml (P < 0.0001). Alongside bioactivity analysis phytochemical fingerprints were made, with the aim to understand important substance classes contained. Further investigations are required to explore the active principles.Our study shows that an ethnopharmacological approach based on historical records of traditional use to select potential herbal candidates coupled with a rational screening process enables an efficient search for plant-derived natural products with antiviral activity against SARS-CoV-2.

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Medicinal Plants Against SARS-CoV/Corona Virus Infections: Ethnopharmacology, Chemistry, Clinical, and Preclinical Studies

Andole

Thumma

Kusuma

et al. 2023

Reference Series in Phytochemistry

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Editorial: Ethnopharmacological Responses to the Coronavirus Disease 2019 Pandemic

Cited by 6 publications

References 34 publications

Experiences and challenges of African traditional medicine: lessons from COVID-19 pandemic

Experiences and challenges of African traditional medicine: lessons from COVID-19 pandemic

Historical texts as a potential resource for plant-derived natural products against SARS-CoV-2 – the example of theReceptariumof Burkhard III von Hallwyl from 16th century Switzerland

Medicinal Plants Against SARS-CoV/Corona Virus Infections: Ethnopharmacology, Chemistry, Clinical, and Preclinical Studies

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