Editorial for the Special Issue “Acute and Chronic Pancreatitis, Pancreatic Malignancies”

Gulbinas, Antanas; Ignatavičius, Povilas; Dambrauskas, Žilvinas

doi:10.3390/medicina59050984

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…CP can often be attributed to several prevalent risk factors, including excessive alcohol consumption, smoking, and genetic mutation [2,[11][12][13]. Notably, alcohol use and smoking are well-established risk factors for various types of cancer.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data

Hsieh

et al. 2023

JCM

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Chronic pancreatitis (CP) may induce systemic inflammation, potentially increasing cancer susceptibility. However, the link between CP and extra-pancreatic cancer remains underexplored. Employing Taiwanese National Health Insurance Database data from 2000 to 2017, we compared 5394 CP patients with 21,576 non-CP individuals through propensity score matching. CP patients exhibited a significantly higher cancer risk (adjusted hazard ratio (aHR) of 1.32 for females and 1.68 for males) and cumulative incidence (p < 0.001) compared to non-CP individuals. CP showed notable associations with pancreatic (aHR = 3.51), liver (aHR = 1.62), stomach (aHR = 2.01), and other cancers (aHR = 2.09). In terms of liver cancer, CP was significantly associated with patients without viral hepatitis, regardless of gender (aHR = 2.01 for women; aHR = 1.54 for men). No significant cancer occurrences were observed within the first year following CP diagnosis. Pancreatic or liver cancer developed in approximately half of CP patients within 2–3 years, while gastric cancer in male CP patients predominantly occurred around the fifth year after diagnosis. These findings inform potential cancer-screening plans for CP patients.

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Section: Introductionmentioning

confidence: 99%

The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data

Hsieh

et al. 2023

JCM

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“…The pathogenesis of AP remains largely elusive, with premature intracellular protease activation and oxidative stress among the suggested mechanisms underpinning disease onset [3]. Once activated, these intracellular proteases induce acinar cell injury, causing cell membrane disruption, edema, interstitial hemorrhaging, and necrosis and igniting an inflammatory response marked by leukocyte infiltration [4].…”

Section: Introductionmentioning

confidence: 99%

Unraveling the Metabolic Changes in Acute Pancreatitis: A Metabolomics-Based Approach for Etiological Differentiation and Acute Biomarker Discovery

Dancu,

Tarta,

Socaciu

et al. 2023

Biomolecules

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Acute pancreatitis (AP) remains a challenging medical condition, where a deeper metabolic insight could pave the way for innovative treatments. This research harnessed serum metabolomics to discern potential diagnostic markers for AP and distinguish between its biliary (BAP) and alcohol-induced (AAP) forms. Leveraging high-performance liquid chromatography coupled with mass spectrometry, the metabolic signatures of 34 AP patients were contrasted against 26 healthy participants, and then between different etiologies of AP. The results identified metabolites primarily from glycerophospholipids, glycerolipids, fatty acyls, sterol lipids, and pteridines and derivative classes, with the Human Metabolome Database aiding in classification. Notably, these metabolites differentiated AP from healthy states with high AUROC values above 0.8. Another set of metabolites revealed differences between BAP and AAP, but these results were not as marked as the former. This lipidomic analysis provides an introduction to the metabolic landscape of acute pancreatitis, revealing changes in multiple lipid classes and metabolites and identifying these metabolites. Future research could add and discover new diagnostic biomarkers and therapeutic strategies enhancing the management of acute pancreatitis.

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Editorial for the Special Issue “Acute and Chronic Pancreatitis, Pancreatic Malignancies”

Abstract: Pancreatic diseases, especially acute pancreatitis and pancreatic cancer, are associated with high rates of complications, difficult treatment that may not always be effective, and high mortality in complex cases [...]

Cited by 2 publications

References 25 publications

The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data

The Impact of Chronic Pancreatitis on the Occurrences of Human Cancers: Real-World Data

Unraveling the Metabolic Changes in Acute Pancreatitis: A Metabolomics-Based Approach for Etiological Differentiation and Acute Biomarker Discovery

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