Editorial: From the hydrophobic core to the globular-disorder interface: New challenges and insights into protein design

Plot-Tools in Protein Structure Validations: From the Ramachandran Plot to the Complementarity Plot (Commentary)

“…In molecular biophysics, the protein folding problem is one of the major unsolved (at least partially) problems branching out in a trifurcated way to (i) the thermodynamic problem, (ii) the kinetic problem and (iii) the structure prediction problem. Although the structure prediction problem (said to be the 'holy grail' of structural biology) have lately drawn much attention of the community through the success of deep learning and Alpha-Fold, the biophysical basis of protein folding still remain largely unexplained [2]. One of the related problems especially for protein crystallographers and other members of the experimental structural biology fraternity is the structure validation problem.…”