Editorial: Frontiers in Autoimmune Disease: Rheumatic Fever and Rheumatic Heart Disease

Guilherme, Luiza; Köhler, Karen; Faé, Kellen C.

doi:10.3389/fped.2015.00091

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…However, there is little contemporary information on presentation, complications and treatment of RHD. Several molecules that play a role in the immune response against the bacteria might be involved in the mechanisms leading to autoimmune reactions [ 40 ]. ACE is a zinc metallopeptidase, and makes important contributions to many different physiological processes [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Correlation of angiotensin I-converting enzyme gene insertion/deletion polymorphism with rheumatic heart disease: a meta-analysis

Tian

et al. 2016

Bioscience Reports

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Rheumatic heart disease (RHD) is a serious cardiovascular disorder worldwide. Several articles have reported the effect of angiotensin I-converting enzyme gene insertion/deletion (ACE I/D) polymorphism in RHD risk. However, the results still remain inconsistent. The objective of the present study was to assess more precise estimations of the relationship between ACE I/D variant and RHD susceptibility. Relevant case–control studies published between January 2000 and 2016 were searched in the electronic databases. The odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the strength of the effect. A total of nine articles were retrieved, including 1333 RHD patients and 1212 healthy controls. Overall, our result did not detect a significant association between ACE I/D polymorphism and RHD risk under each genetic model (P > 0.05). Subgroup analysis by ethnicity showed no positive relationship in Asians as well (P > 0.05). With respect to the severity of RHD, our result found that the frequency differences between mitral valve lesion (MVL), combined valve lesion (CVL) and healthy controls were not significantly different. Furthermore, no significant association was found between female, male RHD patients and the controls regarding to the ACE I/D polymorphism. In conclusion, our result indicated that ACE I/D polymorphism might not be a risk factor for RHD progression based on the existing research results. Additional well-designed studies with larger samples are still needed to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Correlation of angiotensin I-converting enzyme gene insertion/deletion polymorphism with rheumatic heart disease: a meta-analysis

Tian

et al. 2016

Bioscience Reports

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“…These aberrant responses involve complex interactions between surface-expressed Strep A antigens and components of the innate and adaptive immune system and intracellular and extracellular proteins in a susceptible host [24,56,57].…”

Section: The Host Immune Response To Strep Amentioning

confidence: 99%

Rheumatic heart disease: A review of the current status of global research activity

Dooley

Ahmad

Pandey

et al. 2021

Autoimmunity Reviews

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Molecular Mimicry, Autoimmunity, and Infection: The Cross-Reactive Antigens of Group A Streptococci and their Sequelae

Cunningham¹

2019

Gram-Positive Pathogens

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Editorial: Frontiers in Autoimmune Disease: Rheumatic Fever and Rheumatic Heart Disease

Cited by 4 publications

References 11 publications

Correlation of angiotensin I-converting enzyme gene insertion/deletion polymorphism with rheumatic heart disease: a meta-analysis

Correlation of angiotensin I-converting enzyme gene insertion/deletion polymorphism with rheumatic heart disease: a meta-analysis

Rheumatic heart disease: A review of the current status of global research activity

Molecular Mimicry, Autoimmunity, and Infection: The Cross-Reactive Antigens of Group A Streptococci and their Sequelae

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