Editorial: Frontiers in bacterial quorum sensing research

Chen, Lin; Ku, Lina; Li, Mingkai

doi:10.3389/fcimb.2022.999388

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…The polynomial-fitting curve revealed an overall upward trend for the number of annual publications, thereby identifying it as a hot research field. [15,16]…”

Section: Discussionmentioning

confidence: 99%

“…The polynomial-fitting curve revealed an overall upward trend for the number of annual publications, thereby identifying it as a hot research field. [15,16] A visual examination of the distribution of countries and institutions revealed that the United States contributed the largest number of citations and had the greatest number of co-authors, thereby indicating that the United States is the epicenter of research on bacterial QS. Although China ranks second in terms of publications, the average number of citations per paper is only 19.35, thereby suggesting that efforts should be made to improve study quality.…”

Section: Global Publication Trendsmentioning

confidence: 99%

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Global Trends in and Hotspots of Bacterial Quorum Sensing: A Bibliometric Analysis for the Period 2012–2022

Miao,

Han,

Gao

et al. 2024

Integr Med Nephrol Androl

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Background: Bacterial quorum sensing (QS) plays significant roles in various fields. However, a comprehensive understanding of publication trends and research focuses within this domain remains limited. This study aimed to analyze global trends and hotspots of QS through a bibliometric analysis. Methods: The literature collected from the Web of Science Core Collection (WoSCC) database from 2012 to 2022 was retrieved, and then the bibliometric and visualization analyses were conducted using Co-Occurrence 13.4 (COOC), VOSviewer 1.6.19, and Pajek 5.16. Results: A total of 7506 papers were included and analyzed. The results revealed that the number of papers in the field of QS has increased rapidly in the last decade. The United States was the most productive and the most cited. China ranked second in terms of publications. The Chinese Academy of Science and The University of Copenhagen were the most active institutions in the field. Bonnie L. Bassler was the top-ranked author in terms of citations, thereby indicating that she was a leader in terms of academic influence in the area of QS. Further, the analysis of keywords revealed that previous studies focused on the basic mechanism, but recent research focuses on the more profound exploration of signal molecules and information exchange. Quorum quenching (QQ) and quorum sensing inhibitors (QSIs) provide directions for addressing bacterial resistance and pave the way for the development of new antimicrobial agents, which has become a hotspot and the key direction for future development in microbiological research. Conclusion: Our analysis provides a comprehensive overview of publication trends, research hotspots, and frontiers, which may provide guidelines for future research of QS.

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“…The polynomial-fitting curve revealed an overall upward trend for the number of annual publications, thereby identifying it as a hot research field. [15,16]…”

Section: Discussionmentioning

confidence: 99%

Section: Global Publication Trendsmentioning

confidence: 99%

Global Trends in and Hotspots of Bacterial Quorum Sensing: A Bibliometric Analysis for the Period 2012–2022

Miao,

Han,

Gao

et al. 2024

Integr Med Nephrol Androl

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“…QS products such as extracellular proteases have a metabolic expense but provide community level fitness benefits, hence collaborative production acts to limit individual cost [ 161 ]. Many QS-mediated products are virulence factors that facilitate processes such as biofilm formation, integrity promotion and dispersal associated with systemic disease progression [ 160 , 162 ].…”

Section: Therapeutically Relevant Skin-microbiome-derived Compoundsmentioning

confidence: 99%

Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products

Nicholas-Haizelden,

Murphy,

Hoptroff

et al. 2023

Microorganisms

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Bioprospecting is the discovery and exploration of biological diversity found within organisms, genetic elements or produced compounds with prospective commercial or therapeutic applications. The human skin is an ecological niche which harbours a rich and compositional diversity microbiome stemming from the multifactorial interactions between the host and microbiota facilitated by exploitable effector compounds. Advances in the understanding of microbial colonisation mechanisms alongside species and strain interactions have revealed a novel chemical and biological understanding which displays applicative potential. Studies elucidating the organismal interfaces and concomitant understanding of the central processes of skin biology have begun to unravel a potential wealth of molecules which can exploited for their proposed functions. A variety of skin-microbiome-derived compounds display prospective therapeutic applications, ranging from antioncogenic agents relevant in skin cancer therapy to treatment strategies for antimicrobial-resistant bacterial and fungal infections. Considerable opportunities have emerged for the translation to personal care products, such as topical agents to mitigate various skin conditions such as acne and eczema. Adjacent compound developments have focused on cosmetic applications such as reducing skin ageing and its associated changes to skin properties and the microbiome. The skin microbiome contains a wealth of prospective compounds with therapeutic and commercial applications; however, considerable work is required for the translation of in vitro findings to relevant in vivo models to ensure translatability.

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“…To improve quorum sensing in bacteria, researchers are experimenting with synthetic analogs or created variations of these molecules. According to Johnson and Lee (2021) this makes it possible to precisely regulate the amount and timing of anticancer agent synthesis.…”

Section: Exploiting Quorum Sensingmentioning

confidence: 99%

Challenges of Breast Cancer Treatment through Microbial Therapeutic Delivery

2023

Microb Bioacts

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Breast cancer remains a significant global health concern, necessitating innovative approaches for its treatment. Using bacteria as vehicles for therapeutic delivery has emerged as a promising strategy. As a group of prokaryotic microorganisms, bacteria have great potential for use in cancer therapy. Thus, strategies for treating breast cancer need to be continuously refined to achieve a better patient outcome. This manuscript explores the potential of bacterial-based therapies for breast cancer treatment, elucidating the mechanisms underlying their application, safety considerations, and recent advancements. Nevertheless, notable challenges in bacterial-based cancer treatments include potential cytotoxicity, incomplete cancer cell lysis, and the risk of genomic mutations. With an emphasis on engineering bacteria to target and deliver therapeutic agents specifically to tumor sites, this manuscript provides insights into the future of personalized, precise, and effective breast cancer treatment.

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Editorial: Frontiers in bacterial quorum sensing research

Cited by 5 publications

References 8 publications

Global Trends in and Hotspots of Bacterial Quorum Sensing: A Bibliometric Analysis for the Period 2012–2022

Global Trends in and Hotspots of Bacterial Quorum Sensing: A Bibliometric Analysis for the Period 2012–2022

Bioprospecting the Skin Microbiome: Advances in Therapeutics and Personal Care Products

Challenges of Breast Cancer Treatment through Microbial Therapeutic Delivery

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