Editorial: Gender Differences in Cardiovascular Diseases

Zhou, Qing; Bei, Yihua

doi:10.1007/s12265-020-09956-9

Cited by 17 publications

(14 citation statements)

References 13 publications

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“…A rising number of pluripotent stem cell-based therapies to treat myocardial infarction have been proposed. However, only marginal improvements in cardiac function have been reported from rodents to large animal models [ 47 , 48 , 49 ]. Here, we demonstrated (1) that the intramyocardial injection of 10 million early-stage hiPSC-CMs seven days after MI improved LV segmental performance on infarcted rats.…”

Section: Discussionmentioning

confidence: 99%

In Situ Maturated Early-Stage Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Improve Cardiac Function by Enhancing Segmental Contraction in Infarcted Rats

Biagi

Fantozzi

Campos-Oliveira

et al. 2021

JPM

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The scant ability of cardiomyocytes to proliferate makes heart regeneration one of the biggest challenges of science. Current therapies do not contemplate heart re-muscularization. In this scenario, stem cell-based approaches have been proposed to overcome this lack of regeneration. We hypothesize that early-stage hiPSC-derived cardiomyocytes (hiPSC-CMs) could enhance the cardiac function of rats after myocardial infarction (MI). Animals were subjected to the permanent occlusion of the left ventricle (LV) anterior descending coronary artery (LAD). Seven days after MI, early-stage hiPSC-CMs were injected intramyocardially. Rats were subjected to echocardiography pre-and post-treatment. Thirty days after the injections were administered, treated rats displayed 6.2% human cardiac grafts, which were characterized molecularly. Left ventricle ejection fraction (LVEF) was improved by 7.8% in cell-injected rats, while placebo controls showed an 18.2% deterioration. Additionally, cell-treated rats displayed a 92% and 56% increase in radial and circumferential strains, respectively. Human cardiac grafts maturate in situ, preserving proliferation with 10% Ki67 and 3% PHH3 positive nuclei. Grafts were perfused by host vasculature with no evidence for immune rejection nor ectopic tissue formations. Our findings support the use of early-stage hiPSC-CMs as an alternative therapy to treat MI. The next steps of preclinical development include efficacy studies in large animals on the path to clinical-grade regenerative therapy targeting human patients.

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Section: Discussionmentioning

confidence: 99%

In Situ Maturated Early-Stage Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Improve Cardiac Function by Enhancing Segmental Contraction in Infarcted Rats

Biagi

Fantozzi

Campos-Oliveira

et al. 2021

JPM

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“…The number of people estimated to be affected by diabetes by 2045 is about 693 million [11]. Diabetes as a chronic non-communicable disease is one of the leading causes of death, due to a high incidence of cardiovascular complications and especially atherosclerosis as major cardiovascular disease (CVD) [12]. Atherosclerosis is considered as a leading cause of morbidity and mortality in both men and women.…”

Section: Discussionmentioning

confidence: 99%

“…One of the reasons that men are at high risk of developing atherosclerosis can be explained in part by their propensity to adopt risky behaviors such as smoking or excessive alcohol consumption [20], [21]. In addition, men and women exhibit differences in heart structure and function, sex hormones and sociopsychological characteristics [12]. However, after menopause, the risk of atherosclerosis-related diseases begins to increase in women and may even exceed that of men [13].…”

Section: Discussionmentioning

confidence: 99%

Impact of Gender Differences and Glycated Haemoglobin on Atherosclerosis Risk in Type 2 Diabetic Patients from North Western Algeria

2020

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In type 2 diabetic patients, blood lipids and lipid ratios have been proven to be associated with atherosclerosis risk; however, results about the effect of gender differences had not been fully conclusive. In this transversal comparative study, a total of 129 adult type 2 diabetic patients (54 men and 75 women), from north western Algeria, was included to highlight the impact of gender differences on atherosclerosis risk (assessed by lipid ratios) according to their diabetic profile. Comparing between the two genders, no significant differences (p>0.05) were noted on diabetes duration, central obesity, body mass index and blood pressures. Moreover, the basic biochemical parameters of both glycaemic and lipid metabolism were not meaningfully divergent. However, higher significant values (p<0.05) of body weight, height, HbA1c levels, HDL and lipid ratios (TC/HDL, LDL/HDL and TG/HDL) were observed in male patients comparing to females. According to the HbA1c levels (HbA1c<7%vs. HbA1c≥ 7%); notable higher CT/HDL, LDL/HDL and TG/HDL in male patients comparing to women were found. The rates of these three lipid ratios were often higher in both classes of HbA1c. The consideration of gender differences is very important for prevention, diagnosis, treatment and management of atherosclerosis and CVD. The disparity in atherogenic risk, in both genders, estimated by lipid ratios need to be critically examined. Further, interventional studies are needed to determine how sex can modulate the impacts of diabetes control parameters on atherosclerosis risk.

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“…An experimental study investigating the antioxidant and anti-inflammatory effects of tanshinone IIA in rat cardiomyocytes during oxidative stress injury suggested that these functions originate from the Nrf2 pathway [ 75 ]. Similarly, some other studies using various experimental and clinical data concluded that the up-regulation of Nrf2 mitigates the escalation of hemodynamic stress and prevents the resultant heart failure; thus, it could be a potential therapeutic target for cardiovascular diseases caused by IRI [ 73 , 76 , 77 ]. Additionally, several studies proposed that epidermal growth factor (EGF) has a vital role in the Nrf2 pathway, as activation of EGF receptor (EGFR) enables the nuclear translocation of Nrf2 by inhibiting Keap1 to carry out the antioxidant activities following transcription of NQO1 and HO-1 [ 78 ].…”

Section: Role Of Nrf2/keap1/are Pathway In Irimentioning

confidence: 97%

Pharmacological Protection against Ischemia-Reperfusion Injury by Regulating the Nrf2-Keap1-ARE Signaling Pathway

Uçar

Saha³

et al. 2021

Antioxidants

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Ischemia/reperfusion (I/R) injury is associated with substantial clinical implications, including a wide range of organs such as the brain, kidneys, lungs, heart, and many others. I/R injury (IRI) occurs due to the tissue injury following the reestablishment of blood supply to ischemic tissues, leading to enhanced aseptic inflammation and stimulation of oxidative stress via reactive oxygen and nitrogen species (ROS/RNS). Since ROS causes membrane lipids’ peroxidation, triggers loss of membrane integrity, denaturation of proteins, DNA damage, and cell death, oxidative stress plays a critical part in I/R pathogenesis. Therefore, ROS regulation could be a promising therapeutic strategy for IRI. In this context, Nrf2 (NF-E2-related factor 2) is a transcription factor that regulates the expression of several factors involved in the cellular defense against oxidative stress and inflammation, including heme oxygenase-1 (HO-1). Numerous studies have shown the potential role of the Nrf2/HO-1 pathway in IRI; thus, we will review the molecular aspects of Nrf2/Kelch-like ECH-associated protein 1 (Keap1)/antioxidant response element (ARE) signaling pathway in I/R, and we will also highlight the recent insights into targeting this pathway as a promising therapeutic strategy for preventing IRI.

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Editorial: Gender Differences in Cardiovascular Diseases

Cited by 17 publications

References 13 publications

In Situ Maturated Early-Stage Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Improve Cardiac Function by Enhancing Segmental Contraction in Infarcted Rats

In Situ Maturated Early-Stage Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Improve Cardiac Function by Enhancing Segmental Contraction in Infarcted Rats

Impact of Gender Differences and Glycated Haemoglobin on Atherosclerosis Risk in Type 2 Diabetic Patients from North Western Algeria

Pharmacological Protection against Ischemia-Reperfusion Injury by Regulating the Nrf2-Keap1-ARE Signaling Pathway

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