Editorial: Heterotopic ossification

Nilsson, Olle

doi:10.3109/17453679809117606

Cited by 16 publications

(12 citation statements)

References 25 publications

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“…The awareness of these side effects has grown during the last decade. Today, most clinicians would probably agree that NSAID prophylaxis should only be recommended for those who are considered to be at risk of developing severe HO [11]. Our conclusions are that HO following THA for a femoral neck fracture, despite frequent occurrence, is of little clinical importance for this category of patients and that NSAID prophylaxis can and should be restricted.…”

Section: Discussionmentioning

confidence: 85%

“…The clinical symptoms of severe HO, after THA due to osteoarthritis, have been referred to as lesser gain in range of motion postoperatively [1,2,11]. Many patients 224 with osteoarthritis have a limited range of motion preoperatively, which differs from the situation in fracture patients.…”

Section: Discussionmentioning

confidence: 99%

“…Heterotopic ossification (HO) is a common and welldocumented complication following hip arthroplasty [2,5,8,11]. Widely differing incidence rates have been reported, from very high (90%) after Moore arthroplasties for femoral neck fractures [15] to the low incidence of 5% after Charnley arthroplasties for osteoarthritis [6].…”

Section: Introductionmentioning

confidence: 99%

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Heterotopic ossification following internal fixation or arthroplasty for displaced femoral neck fractures: a prospective randomized study

Johansson

Risto

Knutsson

et al. 2001

International Orthopaedics (SICOT)

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One hundred hips in 99 patients of 75 years or older, with a displaced femoral neck fracture, were studied for heterotopic ossification (HO). The patients were randomized to either internal fixation or total hip arthroplasty (THA). In the THA group HO was found in 32 of 45 hips compared with 1 of 39 in the internal fixation group (P<0.0012). The frequency of HO after THA corresponds well with findings in other studies on patients receiving THA for osteoarthrosis. In cervical fractures the surgical procedure of total hip replacement seems to be a prerequisite for HO, indicating that the procedure itself is more important than the patient's age and the diagnosis. Severe symptoms due to HO were found in only one patient. HO following THA for a femoral neck fracture is of little clinical importance and prophylaxis is unnecessary.Résumé Nous avons étudié la fréquence des ossification hétérotopiques (OH) dans 100 hanches chez 99 patients âgés de 75 ans ou plus, avec une fracture déplacée du col du fémur. Les patients ont été randomisés pour un traitement soit par fixation interne soit par arthroplastie totale de la hanche. Dans le groupe des arthroplasties on a trouvé 32/45 hanches avec des ossifications et 1/39 dans le groupe fixation interne (P<0.0012). La fréquence des ossifications après arthroplastie correspond à celle retrouvée dans les cas de coxarthrose. Dans les fractures cervicales la procédure de remplacement prothétique paraît être une condition préalable à la survenue d'ossifications, en indiquant que la procédure elle-même est plus importante que l'âge et le diagnostic. Des symptômes graves dus aux ossifications ont été retrouvés seulement chez un patient. Les ossifications hétérotopiques après une prothèse totale de la hanche pour fracture du col du fémur ont peu d'importance et la prophylaxie est inutile.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Heterotopic ossification following internal fixation or arthroplasty for displaced femoral neck fractures: a prospective randomized study

Johansson

Risto

Knutsson

et al. 2001

International Orthopaedics (SICOT)

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“…Heterotopic ossification (HO) is a process of bone formation at ectopic sites, such as muscle and connective tissue, that can lead to decreased mobility, pain, or even total ankylosis (1,2). Heterotopic ossification is the major complication following traumatic acetabular fracture, head and neck traumas, and total hip arthroplasty.…”

mentioning

confidence: 99%

Disulfide Bridge Conformers of Mature BMP Are Inhibitors for Heterotopic Ossification

Weber

Eyrich

Grätz

et al. 2001

Biochemical and Biophysical Research Communications

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“…However, the identification of some risk factors has led to the use of preventive treatment to limit the onset of HO and has resulted in theories on the pathogenesis HO formation. Systemic and local risk factors of HO have been identified [1][2][3]. The former include sex (male predominance), old age, obesity, osteoporosis and concomitant diseases, such as hypertrophic arthritis, ankylosing spondylitis, Parkinson's disease, and cranial and spinal cord injuries.…”

Section: Discussionmentioning

confidence: 99%

Heterotopic ossification after total hip replacement and the HLA system in the Sicilian population

Sessa

Costarella

Mollica

et al. 2002

J Orthopaed Traumatol

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Editorial: Heterotopic ossification

Cited by 16 publications

References 25 publications

Heterotopic ossification following internal fixation or arthroplasty for displaced femoral neck fractures: a prospective randomized study

Heterotopic ossification following internal fixation or arthroplasty for displaced femoral neck fractures: a prospective randomized study

Disulfide Bridge Conformers of Mature BMP Are Inhibitors for Heterotopic Ossification

Heterotopic ossification after total hip replacement and the HLA system in the Sicilian population

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