Editorial: Hormone Receptors and Breast Cancer

Brunetti, Antonio; Manfioletti, Guidalberto

doi:10.3389/fendo.2019.00205

Cited by 12 publications

(8 citation statements)

References 17 publications

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“…Breast cancer is one of the leading causes of mortality among women worldwide. Hormones and hormone receptors play important roles in the etiology of breast cancer ( Brunetti and Manfioletti, 2019 ). Estrogen exerts a positive effect on cancer cell proliferation ( Lumachi et al, 2015 ), with estrogen receptor (ER)-positive (+) breast cancer accounting for approximately 80% of total breast cancer cases globally.…”

Section: Introductionmentioning

confidence: 99%

Ursolic Acid Decreases the Proliferation of MCF-7 Cell-Derived Breast Cancer Stem-Like Cells by Modulating the ERK and PI3K/AKT Signaling Pathways

Kim

2021

Prev. Nutr. Food Sci.

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Cancer stem cells are strong drivers of metastasis and cancer relapse, which makes them important therapeutic targets. Ursolic acid (UA), a pentacyclic triterpenoid, has anticancer effects in various types of cancer; however, little is known about its effect on the growth of MCF-7 cell-derived breast cancer stem (BCS)-like cells in estrogen receptor positive breast cancer. In this study, the anticancer activity of UA in MCF-7 cell-derived BCS-like cells and its mechanism of action were evaluated. Furthermore, its inhibitory effects on the proliferation of MCF-7 cell-derived BCS-like cells were compared with that on MCF-7 cells. In MCF-7 cells, UA increased p53 and p21 expression but decreased cyclin D, cyclin E, CDK4, and CDK2 expression to induce cell cycle arrest in the G0/G1 phase. Moreover, UA significantly suppressed migration, invasion, and colony formation in MCF-7 cells, and suppressed mammosphere formation in a concentration-dependent manner. In MCF-7 cell-derived BCS-like cells, UA significantly decreased migration, suppressed p-PI3K, p-AKT, and p-ERK expression, and enhanced p-FoxO1/FoxO3a expression. Accordingly, in MCF-7 cell-derived BCS-like cells, UA suppressed proliferation in part by downregulating ERK and PI3K/AKT signaling pathways. These findings provide the first evidence for the selective effects of UA in BCSs.

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Section: Introductionmentioning

confidence: 99%

Ursolic Acid Decreases the Proliferation of MCF-7 Cell-Derived Breast Cancer Stem-Like Cells by Modulating the ERK and PI3K/AKT Signaling Pathways

Kim

2021

Prev. Nutr. Food Sci.

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“…It also contributes to the fact that there is little information and published texts that 100% confirm the side effects for the final consumers of meat containing residues of anabolic substances that cannot be neutralized. However, many studies based on epidemiological studies draw attention to the relationship of hormonal residues in food with cancer [ 14 , 15 , 23 , 24 , 25 ].…”

Section: Legislative Measures For the Use Of Aasmentioning

confidence: 99%

Anabolic Steroids in Fattening Food-Producing Animals—A Review

Skoupá

Šťastný

Sládek

2022

Animals

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Anabolic steroids are chemically synthetic derivatives of the male sex hormone testosterone. They are used in medicine for their ability to support muscle growth and healing and by athletes for esthetic purposes and to increase sports performance, but another major use is in fattening animals to increase meat production. The more people there are on Earth, the greater the need for meat production and anabolic steroids accelerate the growth of animals and, most importantly, increase the amount of muscle mass. Anabolic steroids also have proven side effects that affect all organs and tissues, such as liver and kidney parenchymal damage, heart muscle degeneration, organ growth, coagulation disorders, and increased risk of muscle and tendon rupture. Anabolic steroids also have a number of harmful effects on the developing brain, such as brain atrophy and changes in gene expression with consequent changes in the neural circuits involved in cognitive functions. Behavioral changes such as aggression, irritability, anxiety and depression are related to changes in the brain. In terms of long-term toxicity, the greatest impact is on the reproductive system, i.e., testicular shrinkage and infertility. Therefore, their abuse can be considered a public health problem. In many countries around the world, such as the United States, Canada, China, Argentina, Australia, and other large meat producers, the use of steroids is permitted but in all countries of the European Union there is a strict ban on the use of anabolic steroids in fattening animals. Meat from a lot of countries must be carefully inspected and monitored for steroids before export to Europe. Gas or liquid chromatography methods in combination with mass spectrometry detectors and immunochemical methods are most often used for the analysis of these substances. These methods have been considered the most modern for decades, but can be completely ineffective if they face new synthetic steroid derivatives and want to meet meat safety requirements. The problem of last years is the application of “cocktails” of anabolic substances with very low concentrations, which are difficult to detect and are difficult to quantify using conventional detection methods. This is the reason why scientists are trying to find new methods of detection, mainly based on changes in the structure of tissues and cells and their metabolism. This review gathered this knowledge into a coherent form and its findings could help in finding such a combination of changes in tissues that would form a typical picture for evidence of anabolic misuse.

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“…Meat and meat products containing anabolic residues seriously threaten the public health (León et al, 2012;Wolk, 2017). Many studies have drawn attention to the relationship of hormone residues in foods with cancer-based on epidemiological studies (Brunetti & Manfioletti, 2019;Reig & Toldrá, 2008). Hormone and anabolic residues can cause harmful effects including hormonal activities, nervous complications, and vascular stiffness as well as genotoxic effects (Groner & Brown, 2017;Seo et al, 2005).…”

Section: Introductionmentioning

confidence: 99%