Editorial: Immunomodulatory Functions of Fibroblast-like Synoviocytes in Joint Inflammation and Destruction during Rheumatoid Arthritis

Xu, Hanshi; Zheng, Song Guo; Fox, David A.

doi:10.3389/fimmu.2020.00955

Cited by 7 publications

(1 citation statement)

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“…The next predicted gene in our prediction list, HLA-DRA , is also associated with the immune system. As one of the major genes involved in immune recognition processes, it is mainly expressed in antigen-presenting cells, including B cells [ 49 ], mast cells [ 50 ], and fibroblasts [ 51 ]. Therefore, its expression level can be used in distinguishing the three groups of cells from other cells regardless of tissue specificity.…”

Section: Discussionmentioning

confidence: 99%

Identifying Lung Cancer Cell Markers with Machine Learning Methods and Single-Cell RNA-Seq Data

Huang

Zhang

Lei

et al. 2021

Life

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Non-small cell lung cancer is a major lethal subtype of epithelial lung cancer, with high morbidity and mortality. The single-cell sequencing technique plays a key role in exploring the pathogenesis of non-small cell lung cancer. We proposed a computational method for distinguishing cell subtypes from the different pathological regions of non-small cell lung cancer on the basis of transcriptomic profiles, including a group of qualitative classification criteria (biomarkers) and various rules. The random forest classifier reached a Matthew’s correlation coefficient (MCC) of 0.922 by using 720 features, and the decision tree reached an MCC of 0.786 by using 1880 features. The obtained biomarkers and rules were analyzed in the end of this study.

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Section: Discussionmentioning

confidence: 99%