“…Additionally, their chronic clinical conditions may represent a relevant burden for both caregivers and families, next to a significant threat for their health and a cost for medical services (Hickie et al, 2019 ; Kim et al, 2019 ). Covid-19 pandemic dramatically and suddenly exacerbated their fragile health conditions due to unavailability of medical or rehabilitative services and preventive measures such as quarantine and social distancing (Ehrler et al, 2021 ; Jaffee, 2021 ; Masi et al, 2021 ). In fact, their quality of life may be seriously hampered and both caregivers and families's burden may drastically increase (Dhiman et al, 2020 ; Townsend, 2020 ; Farajzadeh et al, 2021 ; Zimmer et al, 2021 ).…”