Editorial: Insights in Alzheimer's disease and related dementias

Ibáñez, Agustín; Reiss, Allison B.; Custodio, Nilton; Alladi, Suvarna

doi:10.3389/fnagi.2022.1068156

Cited by 1 publication

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although Alzheimer's disease itself might not directly cause death, in its advanced stages, it can make people more prone to other conditions that might lead to death [ 17 ]. Additionally, Alzheimer's disease is a primary contributor to disability, dependency, and mortality in older populations [ 19 ]. While there has been considerable progression in understanding how common Alzheimer's disease is and its effects on older individuals, diagnosing the disease has become more complicated [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Biomarkers for Alzheimer’s Disease: Plasma Neurofilament Light and Cerebrospinal Fluid

Abukuri

2024

International Journal of Alzheimer's Disease

View full text Add to dashboard Cite

Neurodegenerative disorders such as Alzheimer’s disease (AD) represent an increasingly significant public health concern. As clinical diagnosis faces challenges, biomarkers are becoming increasingly important in research, trials, and patient assessments. While biomarkers like amyloid-β peptide, tau proteins, CSF levels (Aβ, tau, and p-tau), and neuroimaging techniques are commonly used in AD diagnosis, they are often limited and invasive in monitoring and diagnosis. For this reason, blood-based biomarkers are the optimal choice for detecting neurodegeneration in brain diseases due to their noninvasiveness, affordability, reliability, and consistency. This literature review focuses on plasma neurofilament light (NfL) and CSF NfL as blood-based biomarkers used in recent AD diagnosis. The findings revealed that the core CSF biomarkers of neurodegeneration (T-tau, P-tau, and Aβ42), CSF NFL, and plasma T-tau were strongly associated with Alzheimer’s disease, and the core biomarkers were strongly associated with mild cognitive impairment due to Alzheimer’s disease. Elevated levels of plasma and cerebrospinal fluid NfL were linked to decreased [18F]FDG uptake in corresponding brain areas. In participants with Aβ positivity (Aβ+), NfL correlated with reduced metabolism in regions susceptible to Alzheimer’s disease. In addition, CSF NfL levels correlate with brain atrophy and predict cognitive changes, while plasma total tau does not. Plasma P-tau, especially in combination with Aβ42/Aβ40, is promising for symptomatic AD stages. Though not AD-exclusive, blood NfL holds promise for neurodegeneration detection and assessing treatment efficacy. Given the consistent levels of T-tau, P-tau, Aβ42, and NFL in CSF, their incorporation into both clinical practice and research is highly recommended.

show abstract