Editorial: Laser flare (cell) photometry: 20 years already

Herbort, Carl P.; Tuğal-Tutkun, İlknur

doi:10.1007/s10792-010-9384-x

Cited by 8 publications

(2 citation statements)

References 9 publications

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“…In current practice, methods for assessing disease activity are largely reliant on clinical examination-grading the number of cells and intensity of flare in anterior chamber or vitreous by manual or automated means, or measuring the size of retinal or choroidal lesions. 13 Although fluorescein and indocyanine green angiography offers additional information regarding disease activity, it is an invasive procedure, and not suitable for the frequent testing required to closely titrate treatment to disease activity in the patient. 14 In recent years, the rapid advancement of optical coherence tomography (OCT) technology has allowed non-invasive imaging of the choroid in addition to the retina in cross-section.…”

Section: Introductionmentioning

confidence: 99%

Structural changes of the choroid in sarcoid- and tuberculosis-related granulomatous uveitis

Mehta

Sim

Keane

et al. 2015

Eye

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Aim The aim of this study is to characterise the choroidal features of patients diagnosed with sarcoid-and tuberculosis (TB)-associated granulomatous uveitis using spectral domain optical coherence tomography (OCT). Methods Twenty-seven patients (27 eyes) diagnosed with sarcoid-(13 eyes) and TB (14 eyes)-related uveitis were included in this retrospective, cross-sectional study. Over a sixmonth period, patients diagnosed with sarcoid and TB granulomatous uveitis were scanned using enhanced depth imaging OCT. Clinical and demographical characteristics were recorded, including the method of diagnosis, disease activity, site of inflammation (anterior or posterior), treatments, and visual acuity (VA). Manual segmentation of the choroidal layers was performed using custom image analysis software. Results The main outcome measure was OCT-derived thickness measurements of the choroid and choroidal sublayers (Haller's large vessel and Sattler's medium vessel layers) at the macula region. The ratio of Haller's large vessel to Sattler's medium vessel layer was significantly different at the total macula circle in eyes diagnosed with TB uveitis (1.47 ( = 140.71/95.72 μm)) compared with sarcoid uveitis (1.07 ( = 137.70/128.69 μm)) (P = 0.001). A thinner choroid was observed in eyes with a VA ≥ 0.3 LogMAR (Snellen 6/12; 198.1 μm (interquartile range (IQR) = 147.0-253.4 μm) compared with those with VA o0.3 LogMAR (292.4 μm (IQR = 240.1-347.6 μm)) at the total macula circle (P = 0.004). At the foveal central subfield, the median choroidal thickness was 336.8 μm (IQR = 272.3-375.4 μm) in active compared with 239.3 μm (IQR = 195.3-330.9 μm) in quiescent disease (P = 0.04). Conclusion A disproportionately enlarged Sattler's layer may indicate a diagnosis of sarcoid-related uveitis, and choroidal thickening may be a feature of active granulomatous uveitis.

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Section: Introductionmentioning

confidence: 99%

Structural changes of the choroid in sarcoid- and tuberculosis-related granulomatous uveitis

Mehta

Sim

Keane

et al. 2015

Eye

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“…Young uveitis specialists from Japan were encountered who rely on LFP and have integrated it in their clinical practice and their publications. If there is such a trend, it should find its way into the international literature with increasing reports on measurement of intraocular inflammation using LFP in publications on uveitis cases and uveitis studies [22].…”

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confidence: 99%

The importance of quantitative measurement methods for uveitis: laser flare photometry endorsed in Europe while neglected in Japan where the technology measuring quantitatively intraocular inflammation was developed

Herbort

Tuğal-Tutkun

2016

Int Ophthalmol

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Laser flare photometry (LFP) is an objective and quantitative method to measure intraocular inflammation. The LFP technology was developed in Japan and has been commercially available since 1990. The aim of this work was to review the application of LFP in uveitis practice in Europe compared to Japan where the technology was born. We reviewed PubMed articles published on LFP and uveitis. Although LFP has been largely integrated in routine uveitis practice in Europe, it has been comparatively neglected in Japan and still has not received FDA approval in the USA. As LFP is the only method that provides a precise measure of intraocular inflammation, it should be used as a gold standard in uveitis centres worldwide.Keywords Laser flare photometry Á Uveitis Á Intraocular inflammationIn recent years, tremendous progress has been achieved in quantifying intraocular inflammatory parameters, one of them being laser flare photometry (LFP). Every effort should be done so that objective and quantitative methods replace subjective and obsolete evaluations of inflammation in uveitis practice and uveitis studies. In 1987, one of the authors was present at Tokyo University when there was a lot of activity around the development of a technology that would enable clinicians to measure objectively and quantitatively the level of intraocular inflammation. By optically determining the amount of backscattered light coming from proteins (and cells) in the aqueous produced by a laser beam directed into the anterior chamber, it would be possible, for the first time, to precisely and objectively not only to determine the exact level of intraocular inflammation but also to detect minute changes of flare during follow-up of inflammation. In 1988, the combined efforts of researchers from the

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Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals

Nork

Rasmussen

Christian

et al. 2012

Assessing Ocular Toxicology in Laboratory Animals

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Editorial: Laser flare (cell) photometry: 20 years already

Cited by 8 publications

References 9 publications

Structural changes of the choroid in sarcoid- and tuberculosis-related granulomatous uveitis

Structural changes of the choroid in sarcoid- and tuberculosis-related granulomatous uveitis

The importance of quantitative measurement methods for uveitis: laser flare photometry endorsed in Europe while neglected in Japan where the technology measuring quantitatively intraocular inflammation was developed

Emerging Imaging Technologies for Assessing Ocular Toxicity in Laboratory Animals

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