Editorial: New Antimicrobial Peptides From Bacteria/Invertebrate Obligate Symbiotic Associations

Fodor, Alexandra; Clarke, David J.; Dillman, Adler R.; Tarasco, Eustachio; Hazır, Selçuk

doi:10.3389/fmicb.2022.862198

Cited by 5 publications

(3 citation statements)

References 11 publications

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“…26,42 It is evident that Xenorhabdus strains possess a wide variety of antibacterial components, making them potential sources of novel antibiotics against S. aureus, E. coli, E. cloacae and B. cereus that resist conventional antibiotics. 43 These results were in agreement with those of previous research, which reported that Xenorhabdus produced derivatives of xenocoumacin and amicoumacin, 44,45 each of which has been demonstrated to be an effective antibiotic against S. aureus. 29 All Photorhabdus spp.…”

Section: Discussionsupporting

confidence: 92%

Antimicrobial Activities of Symbiotic and Non-symbiotic Bacteria Associated with the Entomopathogenic Nematode, Steinernema feltiae

Alorabi

2024

J. Pure Appl. Microbiol.

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The use of antibiotics against a range of pathogenic bacteria has increased in recent years, leading to the development of drug resistance, which makes disease control challenging. Thus, the need for the development of new antibacterial medications is critical. Natural resources, such as entomopathogenic bacteria (EPB), provide a rich source of metabolites with well-known antibacterial properties. The present study aimed to investigate the antibacterial activity of symbiotic (n = 1) and non-symbiotic (n = 8) entomopathogenic bacterial species associated with the entomopathogenic nematode (EPN) Steinernema feltiae against four multidrug-resistant bacterial species. Bacterial cells and filtrates from Xenorhabdus bovienii strongly inhibited the growth of Staphylococcus aureus (33.3 and 28.9 mm) and Escherichia coli (24.6 and 21.6 mm) in disk diffusion, minimum inhibitory concentration (MIC) (2 and 8 µl/ml) and minimal bactericidal concentration (MBC) (4 and 12.5 µl/ml) assays. In conclusion, the direct application of endogenous S. feltiae-associated EPB, especially X. bovienii, appears promising as an antibacterial agent against multidrug-resistant bacteria (MRBs).

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Section: Discussionsupporting

confidence: 92%

Antimicrobial Activities of Symbiotic and Non-symbiotic Bacteria Associated with the Entomopathogenic Nematode, Steinernema feltiae

Alorabi

2024

J. Pure Appl. Microbiol.

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“…15 These bacteria generate a wide spectrum of secondary metabolites, some of which have cytotoxic, insecticidal, and antibacterial properties. 11,[16][17][18] The following substances have been shown to be antimicrobial: 3,5-dihydroxy-4isopropystilbene, 12 1-carbapen-2-em-3-carboxylic acid, 13 benzaldehyde, 15 3-hydroxy-2-isopropyl-5-phenethylphenyl carbamate, 19 2-isopropyl-5-(3-phenyl-2-oxiranyl0-benzene-1,3diol, 20 and chaiyaphumine. 21 However, there is limited information on the antibiotic activity of the bacteria associated with EPNs from southwestern Saudi Arabia.…”

Section: Introductionmentioning

confidence: 99%

Isolation, Identification and Antimicrobial Activities of Four Bacteria Associated with Entomopathogenic Nematodes, Steinernema spp.

Alzahrani¹

2023

J. Pure Appl. Microbiol.

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Recently, the search for novel products derived from natural sources has become necessary due to the decreasing effectiveness of current antibiotics in treating bacteria that are antibiotic-resistant. In this context, it is well known that entomopathogenic bacteria (EPBs) produce a broad range of secondary metabolites with antibacterial activities. Therefore, an in-vitro trial was conducted to isolate and identify non-symbiotic bacteria associated with entomopathogenic nematodes, Steinernema spp. and evaluate the antibacterial activity against four antibiotic-resistant bacteria. Four bacterial isolates, i.e. Pseudomonas alcaligenes ST-1, Paenibacillus barcinonensis ST-2, Bacillus mojavensis ST-3, and Bacillus megaterium ST-4 were non-symbiotically isolated from the heamolymph of dead Steinernema-infected Galleria mellonella larvae and molecularly characterized. The bacterial cells and filtrates from P. alcaligenes ST-1 strongly inhibited the growth of Staphylococcus aureus through disk diffusion (43 mm), minimum inhibitory concentration (2.5 µL/mL), and minimal bactericidal concentration (5 µL/mL) assay. Conclusively, the direct application of endogenous Steinernema-associated EPB as an antibacterial agent for antibiotic-resistant bacteria looked promising.

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confidence: 99%

Editorial: Antimicrobial peptides and mRNA therapy: Clinical, Veterinary, and plant pathology perspectives with special attention to combatting MDR pathogens

2022

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KEYWORDSmultidrug resistance (MDR), panresistance, antimicrobial peptide (AMP), AMPencoding mRNA, in vitro transcribed, in vivo translated AMP-encoding mRNA, antimicrobial nucleic acid therapy Editorial on the Research Topic Antimicrobial peptides and mRNA therapy: Clinical, Veterinary and plant pathology perspectives with special attention to combatting MDR pathogens Antimicrobial multidrug resistance (MDR) of the different types is an enormous challenge of clinical, veterinary, and plant pathogenic significance (Fodor et al., 2020). Antimicrobial peptides (AMPs) (Ötvös and Wade, 2014;Upert et al., 2021) are of great potential against MDR pathogens, because (a) the MDR pathogens perform a high frequency of collateral sensitivity to AMPs (Fodor et al., 2022); (b) the mobility patterns of antibiotic resistance and AMP-resistance genes are different (Lázár et al., 2018). The delivery of an exogenous AMP to the right location of a eukaryotic organism is a crucial point. This explains the setting of the ambitious goal to invite authors of manuscripts on delivering in vitro transcribed (exogenous) AMP-into the cell to be protected, in order to translate it to the respective protective AM-peptide in site, following the logic of mRNAbased vaccination (Sahin et al., 2020;Karikó et al., 2021). Unfortunately no manuscript like that was submitted. Instead, we received valuable papers within the larger scope of the RT dealing with perspectives of AMPs solving MDR-related problems.The Research Topics (RT), comprise two Reviews and two Original Research papers from the field of antimicrobial resistance. A Review (Le et al.) discusses the sources and mechanisms of antimicrobial peptides (AMPs) against staphylococcal species including Staphylococcus aureus, S. haemolyticus, Frontiers in Microbiology frontiersin.org

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Editorial: New Antimicrobial Peptides From Bacteria/Invertebrate Obligate Symbiotic Associations

Cited by 5 publications

References 11 publications

Antimicrobial Activities of Symbiotic and Non-symbiotic Bacteria Associated with the Entomopathogenic Nematode, Steinernema feltiae

Antimicrobial Activities of Symbiotic and Non-symbiotic Bacteria Associated with the Entomopathogenic Nematode, Steinernema feltiae

Isolation, Identification and Antimicrobial Activities of Four Bacteria Associated with Entomopathogenic Nematodes, Steinernema spp.

Editorial: Antimicrobial peptides and mRNA therapy: Clinical, Veterinary, and plant pathology perspectives with special attention to combatting MDR pathogens

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