Editorial: New strategies in treatment of differentiated thyroid carcinoma

Abstract

Thyroid carcinoma, treatment strategies in thyroid cancer, thyroid cancer surgery, thyroid cancer diagnosis, thyroid cancer biomarkers, radionuclide I 131, thyroid cancer radiotherapy, thyroid cancer targeted therapy Editorial on the Research Topic New strategies in the treatment of thyroid carcinomaIn this Research Topic of manuscripts on New Strategies In Treatment of Thyroid Carcinoma (TC), edited by the journal Frontiers in Endocrinology, papers have been gathered that, from the perspective of basic sciences, can potentially contribute to provide issues for a better understanding of clinical problems.Moreover, molecular biology and studies designed to improve the intrinsic behavior of papillary carcinoma are pivotal in the development of targeted therapies. The study by Yang el al. tries to ellucidate the role of estrogen receptors on the stimulation of cancer cells, through a significant decrease on the levels of endogenous PPARg ligands PGJ2 and 15(S)-HETE. These findings open a venue to development of endogenous ligands PGJ2 and 15(S)-HETE, to treat papillary thyroid cancer.The role of primary cilia alterations in differentiated TC and its absence in the anaplastic variety is described, as well as its relationship to the presence of the Aurore kinase protein, which is linked to disassembly of these cilia in TC. The article by Ma et al. describes these phenomenae, as well as the possibility of other biochemical pathways implicated with these organelles like Nek1 and Plk1, with the possibility of developing drugs which could restore the physiology of primary cilia of thyroid cells like U0126 and ganetespib.TC has increased its incidence and prevalence during the last 20 years. This is secondary to a better understanding of its presentation, as well as of diagnostic studies performed at present, from which, different image tests like high definition ultrasound, CT scan and aspiration biopsy represent the most relevant ones.On the other hand, a significant number of reports attest to efforts to improve the diagnosis potential of the aforementioned tests. In this e-book the report by Zhang et al., establishes the modification of plasma N-glycome alteration in Thyroid Carcinoma and Frontiers in Endocrinology frontiersin.org 01