Editorial: No-difference Studies Make a Big Difference

Rehabilitation and Physical Therapy before and after Total Knee Arthroplasty: A Literature Review and Unanswered Questions

“…We, however, are taking this opportunity to comment on such studies in this present review. In addition, although many studies may not be able to detect differences in outcomes in patients who performed, or did not perform, the particular rehabilitation, it should be remembered that "no-difference studies make a big difference" [64].…”

Editor’s Spotlight/Take 5: Effectiveness of Preoperative Antibiotics in Preventing Surgical Site Infection After Common Soft Tissue Procedures of the Hand

“…replicated in practice. And insufficient power-failure to detect a betweengroups difference that was in fact present-should always be on our minds as we read no-difference studies [7]. Fortunately, the study in this month's Clinical Orthopaedics and Related Research ® by Dr. Kamal's group addressed these concerns thoughtfully-the propensity-scoring approach used plus the vast number of patients analyzed provide as compelling an answer as we are likely to get on this important topic.…”

Editor's Spotlight/Take 5: The Chitranjan S. Ranawat Award: No Difference in 2-year Functional Outcomes Using Kinematic versus Mechanical Alignment in TKA: A Randomized Controlled Clinical Trial

“…' The authors defined a clinically important difference (five points on the Oxford score), powered the study to detect this difference, and accounted for all of their patients. They reported a set of no-difference conclusions; doing so is critically important [4]. They present the no-difference findings with modesty and clarity, and ask fair questions about the risks associated with a technique they explored.…”