Editorial: Novel mechanisms and approaches in kidney/pancreas-kidney transplant-related injury

Gong, Nianqiao; Zhao, Yuanyuan; Zhu, Hua; Wang, Chenhui

doi:10.3389/fimmu.2022.1082590

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…Antioxidants 2023, 12, x FOR PEER REVIEW 3 of 18 XBP1 was previously shown to result in embryonic lethality [34][35][36][37]. We previously investigated the effects and mechanisms that control homeostasis in the heart and kidneys [8,22,25,26,[38][39][40] and found that oxidative overload is likely to induce or prevent XBP1 mRNA splicing. Furthermore, the efficient activation of XBP1 exerts protective effects on oxidative injury and helps to sustain the viability of the cardiorenal system and the integrity of cardiorenal function [6,41,42].…”

Section: Introductionmentioning

confidence: 99%

XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress

Zhang,

Zhao,

Gong

2023

Antioxidants

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X-box binding protein 1 (XBP1) is a unique basic-region leucine zipper (bZIP) transcription factor. Over recent years, the powerful biological functions of XBP1 in oxidative stress have been gradually revealed. When the redox balance remains undisturbed, oxidative stress plays a role in physiological adaptations and signal transduction. However, during the aging process, increased cellular senescence and reduced levels of endogenous antioxidants cause an oxidative imbalance in the cardiorenal system. Recent studies from our laboratory and others have indicated that these age-related cardiorenal diseases caused by oxidative stress are guided and controlled by a versatile network composed of diversified XBP1 pathways. In this review, we describe the mechanisms that link XBP1 and oxidative stress in a range of cardiorenal disorders, including mitochondrial instability, inflammation, and alterations in neurohumoral drive. Furthermore, we propose that differing degrees of XBP1 activation may cause beneficial or harmful effects in the cardiorenal system. Gaining a comprehensive understanding of how XBP1 exerts influence on the aging cardiorenal system by regulating oxidative stress will enhance our ability to provide new directions and strategies for cardiovascular and renal safety outcomes.

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Section: Introductionmentioning

confidence: 99%

XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress

Zhang,

Zhao,

Gong

2023

Antioxidants

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Predictive value of contrast‐enhanced ultrasonography for the early diagnosis of renal dysfunction after kidney transplantation: A systematic review and meta‐analysis

Zhang,

Li,

Tang

et al. 2024

J of Clinical Ultrasound

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ObjectivesWe aimed to evaluate the changes in renal cortical microperfusion and quantitative contrast‐enhanced ultrasonography (CEUS) parameters after kidney transplantation, and to determine the evidence‐based value of CEUS in predicting renal dysfunction.MethodsThe Embase, MEDLINE, Web of Science, and Cochrane Library databases were searched for relevant studies published from 2000 to 2023 on the use of CEUS to assess the renal cortical microcirculation after kidney transplantation. Subject terms and related keywords were combined, and a meta‐analysis and systematic review were performed according to the Preferred Reporting Items for Systematic reviews and Meta‐Analyses guidelines.ResultsThe search yielded six studies involving 451 patients with moderate to high overall quality. The peak intensity (standardized mean difference [SMD]: −0.64, 95% confidence interval [CI] −1.13 to −0.15, p = 0.01) of CEUS was significantly lower in patients with renal dysfunction than in those with stable renal function. However, the time to peak (SMD: 0.28, 95% CI 0.04 to 0.52, p = 0.02) was significantly shorter in patients with renal dysfunction than in those with stable renal function. The total renal cortical microperfusion and renal cortical perfusion intensity were decreased, and the perfusion time was prolonged, in patients with renal dysfunction after kidney transplantation.ConclusionCEUS parameters can reflect real‐time changes in renal cortical microperfusion, thus providing a basis for the early diagnosis of renal dysfunction after kidney transplantation.

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Endoplasmic reticulum stress signaling modulates ischemia/reperfusion injury in the aged heart by regulating mitochondrial maintenance

Zhang,

Zhao,

Gong

2024

Mol Med

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Aging is associated with an increased risk of myocardial ischemia/reperfusion injury (IRI). With an increasing prevalence of cardiovascular diseases such as coronary arteriosclerosis in older people, there has been increasing interest in understanding the mechanisms of myocardial IRI to develop therapeutics that can attenuate its damaging effects. Previous studies identified that abnormal mitochondria, involved in cellar senescence and oxidative stress, are the master subcellular organelle that induces IRI. In addition, endoplasmic reticulum (ER) stress is also associated with IRI. Cellular adaptation to ER stress is achieved by the activation of ER molecular chaperones and folding enzymes, which provide an important link between ER stress and oxidative stress gene programs. In this review, we outline how these ER stress-related molecules affect myocardial IRI via the crosstalk of ER stress and mitochondrial homeostasis and discuss how these may offer promising novel therapeutic targets and strategies against age-related cardiovascular diseases.

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Editorial: Novel mechanisms and approaches in kidney/pancreas-kidney transplant-related injury

Cited by 3 publications

References 11 publications

XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress

XBP1 Modulates the Aging Cardiorenal System by Regulating Oxidative Stress

Predictive value of contrast‐enhanced ultrasonography for the early diagnosis of renal dysfunction after kidney transplantation: A systematic review and meta‐analysis

Endoplasmic reticulum stress signaling modulates ischemia/reperfusion injury in the aged heart by regulating mitochondrial maintenance

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