Editorial on: Moving Beyond Anatomic Criteria for Resectability: Validation of the Anatomical and Biological Definitions of Borderline Resectable Pancreatic Cancer According to the 2017 International Consensus for Survival and Recurrence in Patients with Pancreatic Ductal Adenocarcinoma Undergoing Upfront Surgery

Paniccia, Alessandro; Zureikat, Amer H.

doi:10.1245/s10434-023-13271-3

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…The resectability status of pancreatic cancer was evaluated according to the 7th edition of the General Rules for the Study of Pancreatic Cancer, published by the Japan Pancreas Society [19]. Patients diagnosed with resectable (n = 5), borderline resectable (n = 29), and locally advanced unresectable pancreatic cancers (n = 1) underwent preoperative therapy with various regimens, such as gemcitabine plus nab-paclitaxel (n = 24), modi ed FOLFIRINOX (5-uorouracil, leucovorin, irinotecan, and oxaliplatin) (n = 2), gemcitabine plus S-1 (n = 8), or chemoradiotherapy with S-1 (n = 1).…”

Section: Treatment For Pancreatic Cancermentioning

confidence: 99%

Impairment of perioperative activities of daily living is associated with poor prognosis following pancreatectomy for pancreatic cancer

Ofuchi,

Mima,

Hayashi

et al. 2024

Preprint

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Purpose The number of patients with pancreatic cancer coping with impaired activities of daily living (ADLs) is continually increasing. This study aimed to examine the association between perioperative Barthel Index (BI) scores, a validated measure of ADLs, and survival outcomes after pancreatectomy for pancreatic cancer. Methods We analyzed the data of 201 patients who underwent pancreatectomy for pancreatic cancer between 2010 and 2020. Preoperative and postoperative ADLs were assessed using the BI (range: 0–100; higher scores indicated greater independence). A preoperative or postoperative BI score ≤ 85 was defined as an impairment of perioperative ADLs. Cox proportional hazards regression was used to calculate the hazard ratios (HRs) after adjusting for potential confounders. Results Among the 201 patients, 14 (7.0%) had a preoperative BI score ≤ 85 and 50 (25%) had a postoperative BI score ≤ 85. Impairment of perioperative ADLs was independently associated with shorter overall survival (multivariable HR: 1.91, 95% confidence interval [95%CI]: 1.04–3.49, P = 0.036), cancer-specific survival (multivariable HR: 1.97, 95%CI: 1.15–3.38, P = 0.013), and recurrence-free survival (multivariable HR: 1.94, 95%CI: 1.08–3.50, P = 0.021). Conclusion Impairment of perioperative ADLs is associated with poor prognosis following pancreatectomy for pancreatic cancer. The maintenance and improvement of perioperative ADLs could play an important role in providing favorable long-term outcomes in patients with pancreatic cancer.

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Section: Treatment For Pancreatic Cancermentioning

confidence: 99%