Editorial on the Special Issue “Comorbidities in Chronic Kidney Disease”

Noels, Heidi; Jankowski, Joachim

doi:10.3390/toxins12060384

Cited by 5 publications

(6 citation statements)

References 35 publications

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“…Renal fibrosis (RF) is a common pathway to end-stage renal failure in a variety of chronic kidney diseases. [1] With an adult prevalence of 13.4% worldwide and still increasing year by year, [2] kidney disease has become an important medical problem worldwide. At present, the progress of clinical control of RF is mainly through the prevention and reversal of fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology and bioinformatics study on the treatment of renal fibrosis with persicae semen-carthami flos drug pair

Wang

Chang

et al. 2023

Medicine

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To use network pharmacology and bioinformatics technology to reveal the mechanism of persicae semen-carthami flos drug pair in the treatment of renal fibrosis (RF). Compounds in traditional Chinese medicine were obtained through the Herb database. Appropriate compounds and corresponding drug targets were screened out based on the 5 rules of Lipinski and pharmacokinetics. Screening of suitable disease miRNAs by microarray chips in the GEO database. Find differentially expressed genes by analyzing miRNAs. Protein-protein interaction analysis and enrichment analysis of therapeutic targets were performed using String database and Omicshare platform. Molecular docking via the DockThor platform. A total of 28 drug compounds and 228 drug targets were screened in this study. A total of 9 miRNAs and 6649 disease targets were obtained by GEO2R software analysis. Finally, 97 therapeutic targets were obtained. A total of 1124 Gene Ontology enrichment analysis results were obtained. Therapeutic targets play multiple roles in biological processes, molecular functions, and cellular organization. Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that the persicae semen-carthami flos drug pair played a role in the treatment of RF mainly through calcium signaling pathway, pathways in cancer, cAMP signaling pathway, and other pathways. Molecular docking showed that the traditional Chinese medicine compounds had good binding ability to the target. Persicae semen and carthami flos play a role in the treatment of RF through multiple targets and multiple pathways. It provides ideas and references for follow-up research and new drug development.Abbreviations: AR = androgen receptor, GO = Gene Ontology, KEGG = Kyoto Encyclopedia of Genes and Genomes, MAPK = mitogen-activated protein kinase, RF = renal fibrosis, UUO = unilateral ureteral obstruction.

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Section: Introductionmentioning

confidence: 99%

Network pharmacology and bioinformatics study on the treatment of renal fibrosis with persicae semen-carthami flos drug pair

Wang

Chang

et al. 2023

Medicine

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“…The characteristics of CKD are similar to those of the aging process; therefore, it has been hypothesized that CKD promotes premature aging associated with related diseases [64]. Furthermore, chronic diseases usually observed in aging, such as CVD, inflammation, vascular calcification, mineral, and bone disorders, and chronodisruption (chronic alteration of circadian rhythms), are markedly frequent in patients with CKD [25].…”

Section: Premature Aging In Chronic Kidney Disease: a Process Associated With An Increase In Cardiovascular Pathologiesmentioning

confidence: 99%

“…Aging is associated with more frequent development of chronic disease pathologies, such as cancer, infectious diseases, diabetes mellitus, obesity, metabolic syndrome, osteoporosis, neurodegenerative diseases, chronic kidney disease (CKD), and cardiovascular disease (CVD) [20][21][22]. Moreover, some age risk factors are smoking, hyperglycemia, hyperlipidemia, obesity, hypertension, dyslipidemia, and loss of bone density and frailty, grouped as metabolic risk factors that can lead to premature death [23][24][25]. All of them are considered metabolic risk factors that join with physical inactivity cause premature aging and the development of associated pathologies such as CVD and/or CKD.…”

Section: Introduction Aging: a Physiological Stage Associated With A Higher Frequency Of Pathologiesmentioning

confidence: 99%

Premature Aging in Chronic Kidney Disease: The Outcome of Persistent Inflammation beyond the Bounds

Figuer

Bodega

Tato

et al. 2021

IJERPH

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Over the last hundred years, life expectancy in developed countries has increased because of healthier living habits and the treatment of chronic pathologies causing premature aging. Aging is an inexorable, time-dependent, multifactorial process characterized by a series of progressive and irreversible physiological changes associated with loss of functional, psychological, and social capabilities. Numerous factors, such as oxidative stress, inflammation, and cellular senescence, and an irreversible geriatric syndrome known as frailty, contribute to human body deterioration in aging. The speed of aging may differ between individuals depending on the presence or absence of multiple factors (genetic and/or environment) and the subsequent misbalance of homeostasis, together with the increase of frailty, which also plays a key role in developing chronic diseases. In addition, pathological circumstances have been reported to precipitate or accelerate the aging process. This review investigated the mechanisms involved in the developing pathologies, particularly chronic kidney disease, associated with aging.

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“…Aside traditional CV risk factors (RF), as diabetes and arterial hypertension, non-traditional RF related to kidney disease per se seem to play a pivotal role in the complex interaction between the kidney and the heart[ 3 ]. Νon-traditional RF include secondary hyperparathyroidism resulting in vascular and valvular calcification, collectively termed as CKD-mineral and bone disorder (CKD-MBD)[ 4 ], uremia per se , inflammation, oxidative stress and dysbiotic gut microbiota[ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Redefying the therapeutic strategies against cardiorenal morbidity and mortality: Patient phenotypes

Bacharaki¹,

Petrakis²,

Stylianou³

2023

World J Cardiol

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Chronic kidney disease (CKD) patients face an unacceptably high morbidity and mortality, mainly from cardiovascular diseases. Diabetes mellitus, arterial hypertension and dyslipidemia are highly prevalent in CKD patients. Established therapeutic protocols for the treatment of diabetes mellitus, arterial hypertension, and dyslipidemia are not as effective in CKD patients as in the general population. The role of non-traditional risk factors (RF) has gained interest in the last decades. These entail the deranged clinical spectrum of secondary hyperparathyroidism involving vascular and valvular calcification, under the term “CKD-mineral and bone disorder” (CKD-MBD), uremia per se , inflammation and oxidative stress. Each one of these non-traditional RF have been addressed in various study designs, but the results do not exhibit any applied clinical benefit for CKD-patients. The “crusade” against cardiorenal morbidity and mortality in CKD-patients is in some instances, derailed. We propose a therapeutic paradigm advancing from isolated treatment targets, as practiced today, to precision medicine involving patient phenotypes with distinct underlying pathophysiology. In this regard we propose two steps, based on current stratification management of corona virus disease-19 and sepsis. First, select patients who are expected to have a high mortality, i.e. , a prognostic enrichment. Second, select patients who are likely to respond to a specific therapy, i.e. , a predictive enrichment.

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Editorial on the Special Issue “Comorbidities in Chronic Kidney Disease”

Abstract: With a mean worldwide prevalence of 13 [...]

Cited by 5 publications

References 35 publications

Network pharmacology and bioinformatics study on the treatment of renal fibrosis with persicae semen-carthami flos drug pair

Network pharmacology and bioinformatics study on the treatment of renal fibrosis with persicae semen-carthami flos drug pair

Premature Aging in Chronic Kidney Disease: The Outcome of Persistent Inflammation beyond the Bounds

Redefying the therapeutic strategies against cardiorenal morbidity and mortality: Patient phenotypes

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