Editorial overview: Low-cost and portable systems for biomedical imaging and sensing

Ceylan Koydemir, Hatice; Ozcan, Aydogan

doi:10.1016/j.cobme.2024.100527

Current Opinion in Biomedical Engineering

2024

DOI: 10.1016/j.cobme.2024.100527

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Editorial overview: Low-cost and portable systems for biomedical imaging and sensing

Hatice Ceylan Koydemir,

Aydogan Ozcan

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2024

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Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope

Loretan,

Barella,

Fuchs

et al. 2024

Preprint

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We present a novel, low-cost, portable smartphone-based fluorescence microscope capable of directly detecting single molecules without signal amplification. The setup leverages the image sensors and data handling capacity of mass-produced smartphones, making it adaptable to any smartphone and capable of detecting single molecules across the visible spectral range. We showcase this capability through single-molecule measurements on DNA origami models and super-resolution microscopy of biological cells by single-molecule localization microscopy. This development paves the way for biotechnology innovations making use of massively distributed or personalized assays with single-molecule sensitivity with the potential to revolutionize digital bioassays, point-of-care diagnostics, field expeditions, STEM outreach, and life science education.

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Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope

Loretan,

Barella,

Fuchs

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Editorial overview: Low-cost and portable systems for biomedical imaging and sensing

Cited by 1 publication

References 6 publications

Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope

Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope

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