2017
DOI: 10.1016/j.cotox.2017.11.006
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Editorial overview of the special issue on genomic toxicology epigenetics

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“…Accumulating evidence suggests that environmental chemicals may alter the epigenome by disrupting cytosine DNA methylation patterns, chromatin structure and expression of noncoding RNAs (Baccarelli and Bollati 2009;Chappell et al 2016;Rusyn and Pogribny 2017). Epigenetic reprogramming has been linked to genomic instability, a hallmark of cancer (Hanahan and Weinberg 2011), and induction of epigenetic alterations is one of key mechanistic characteristics of known human carcinogens (Smith et al 2016).…”
Section: Introductionmentioning
confidence: 99%
“…Accumulating evidence suggests that environmental chemicals may alter the epigenome by disrupting cytosine DNA methylation patterns, chromatin structure and expression of noncoding RNAs (Baccarelli and Bollati 2009;Chappell et al 2016;Rusyn and Pogribny 2017). Epigenetic reprogramming has been linked to genomic instability, a hallmark of cancer (Hanahan and Weinberg 2011), and induction of epigenetic alterations is one of key mechanistic characteristics of known human carcinogens (Smith et al 2016).…”
Section: Introductionmentioning
confidence: 99%