There are few validated positive youth development (PYD) programs in different regions of China. Utilizing 15 PYD constructs extracted from effective programs in the United States and with the support of the Hong Kong Jockey Club Charities Trust, colleagues from five universities in Hong Kong developed the P.A.T.H.S. Program in Hong Kong. In the past two decades, the research team trained 9,415 potential program implementers, supported the implementation in 300 + high schools in Hong Kong (357,839 participants) and evaluated the impact of the project. Because of its overall success, the P.A.T.H.S. Program was transplanted to mainland China with the support of the Tin Ka Ping Foundation, with adaptation of the curriculum materials. Before, during, and after the COVID-19 pandemic, the research team also trained 1,589 teachers and related professionals, provided guidance on the implementation in 30 + schools (84,000 + participants), and evaluated the impact of the program. This paper reviews the achievements, effects, and impact of the P.A.T.H.S. Program in China and beyond. It also highlights several observations and reflections regarding the future development of positive youth development programs in China as well as around the globe.