Editorial: Recent Progresses in Amebiasis

Debnath, Anjan; Rodríguez, Mario A.; Ankri, Serge

doi:10.3389/fcimb.2019.00247

Cited by 11 publications

(7 citation statements)

References 21 publications

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“…Recent progress on research in amebiasis include studies on Entamoeba biology, development of new drugs and the use of genomics and metabolomics (Debnath et al, 2019).…”

Section: Amebiasismentioning

confidence: 99%

Parasites causing cutaneous wounds: Theory and practice from a dermatological point of view

et al. 2022

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“…Recent progress on research in amebiasis include studies on Entamoeba biology, development of new drugs and the use of genomics and metabolomics (Debnath et al, 2019).…”

Section: Amebiasismentioning

confidence: 99%

Parasites causing cutaneous wounds: Theory and practice from a dermatological point of view

et al. 2022

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“…Amebiasis is considered also a tropical neglected disease that caused 55,500 deaths per year worldwide, so far, metronidazole is the only drug to choose (Debnath et al, 2019). Giardiasis is caused by Giardia lamblia however, the resistance to common (metronidazole, tinidazole, and nitazoxanide) antigiardial drugs has increased in recent years (Leung et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

In vitroantiparasitic and antibacterial evaluation of organic extracts of Salvadoran flora

Núñez¹,

Paz-González²,

Vázquez-Jiménez³

et al. 2023

BLACPMA

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Currently, in developing countries, parasitic and bacterial diseases as amebiasis, giardiasis, trichonomiasis, leishmaniasis, trypanosomiasis, tuberculosis, and nocardiasis are a public health problem. The pharmacological treatment for these diseases is not completely effective and causes several side effects in patients. Therefore, the searchfor new compounds with biological activity is very important to develop new drugs safely and more efficiently. In this study, different organic extracts obtained from thirty-seven species of the Salvadoran flora were evaluated in several in vitromodels to determine their potential activity against five protozoa (Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, Leishmania mexicana, and Trypanosoma cruzi) and three bacteria (Acinetobacter baumanni, Mycobacterium tuberculosis, and Nocardia brasiliensis). The results showed the activity of eight extracts with IC50values of less than 100 μg/mL against L. mexicanaand five extracts with MICs values less than <50 μg/mL against M. tuberculosis. Besides, seven plant species showed MICs ≤3.125 μg/mL against N. brasiliensis. Additionally, secondary metabolites (flavonoids and monoterpene oxygenate) previously reported as active were fingerprint by UPLC-MS to establish a potential correlation with the biological activity showed.

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“…However, the infectivity of these CLS in an animal infection model has not yet been determined, and efficient production of mature cysts has not yet been achieved. Thus, modeling the critical developmental stage interconversion that E. histolytica undergoes between ingestion and colonization of the cecum is not yet possible ( 19 ). A model that includes the developmental changes of excystation and encystation would allow the field to understand the transmission of the pathogen and find targets for intervention (reviewed in reference 20 ), as only viable parasites completely encysted and shed via the fecal-oral route can contaminate food and water and infect a new host.…”

Section: Introductionmentioning

confidence: 99%