Rapid industrialization and unplanned urbanization have significantly increased environmental pollution. These human behaviors have resulted in massive waste discharges into the environment. As a result, organic and inorganic contaminants, including heavy metals, have accumulated in surface and groundwater. Heavy metals are highly carcinogenic and deadly. Heavy metal removal from drinking water has always been difficult. Conventional water treatment procedures could be more efficient, wasteful of energy, and generate massive amounts of harmful waste. In this initiative, researchers created a bio-based adsorption technology for removing heavy metal ions from polluted water. Nano celluloses (NCs) as biosorbents have sparked considerable attention due to their unique properties, such as the presence of several -OH groups on their surface, allowing the insertion of chemical moieties, a substantial specific surface area, strong mechanical properties, recyclability, and biodegradability. This review paper goes into great detail regarding the ways of producing Nano cellulose and its essential qualities. Many factors influence the use of NC- based adsorbents in water treatment systems, including synthesis pathways, functionalization of the surface, specific surface area, regeneration capacity, and reusability. Recent advances in bio-sorbent synthesis have prompted using bio-derived NC-based adsorbents in water treatment methods. This study also demonstrates that utilizing the potential for agricultural wastes, specifically sugarcane bagasse (SCB), as a precursor for Nano celluloses represents a sustainable approach, namely the conversion of low-value waste into a specific high-value product and its use in wastewater treatment.