Editorial: Sarcopenia, Frailty and Nutrition in Liver Diseases

Iacob, Speranţa; Beckebaum, Susanne; Dumitraşcu, Dan L.; Gheorghe, Liana

doi:10.3389/fnut.2022.929459

Cited by 1 publication

(1 citation statement)

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“…Given the role of nutrition in both liver disease progression and frailty, the impact of nutritional status and the potential benefits of nutritional interventions warrant further investigation. Nutritional therapy could play a crucial role in reducing frailty and improving HRQoL in CLD patients [ 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Frailty Predicting Health-Related Quality of Life Trajectories in Individuals with Sarcopenia in Liver Cirrhosis: Finding from BCAAS Study

Nathiya,

Raj,

Singh

et al. 2023

JCM

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The association between frailty and health-related quality of life (HRQoL) among Asian patients with liver cirrhosis and sarcopenia remains largely unexplored. To address this knowledge gap, we conducted a cross-sectional study involving individuals aged 32 to 69 years, all diagnosed with liver cirrhosis. The chronic liver disease questionnaire (CLDQ) was used to assess HR-QoL, the CLDQ score was used as an outcome to measure the factors related to HR-QoL, and the liver frailty index (LFI) was used to assess the frailty status. The association between the frailty status and the CLDQ summary scales was investigated using the correlation coefficient and multiple regression analyses. A total of 138 patients in the frail (n = 62) and non-frail (n = 76) groups with (alcohol: 97; viral: 24; autoimmune: 17; and cryptogenic: 12) were included in the study. Age, CTP score, and model for end-stage liver disease (MELD) sodium were significantly higher in the frail group. In the CLDQ domains, there was a significant difference between the frail and non-frail groups (p value = 0.001). In health-related quality-of-life summary measures, there was a strong negative correlation between frailty and the scores for activities, emotional function, and fatigue (p value = 0.001). When comparing frail to non-frail patients, these characteristics demonstrated significantly increased odds as indicated by their adjusted odds ratios: OR 3.339 (p value = 0.013), OR 3.998 (p value = 0.006), and OR 4.626 (p value = 0.002), respectively.

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Section: Discussionmentioning

confidence: 99%