Editorial: Serotonin and Memory

Meneses, Alfredo; Gasbarri, Antonella

doi:10.3389/fphar.2016.00008

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…Building on earlier DCE MRI evaluations of tumor perfusion following VDA treatment [ 106 ], Fruytier et al established that delivery of gemcitabine was diminished in TLT hepatocarcinomas growing intramuscularly in mice 2 h after CA4P. They elegantly showed changes in vascular perfusion and permeability based on DCE-MRI, as well as assessing uptake and metabolic conversion of gemcitabine using 19 F NMR spectroscopy [ 107 ]. Such an approach could allow effective determination of optimal timing of combined therapy by establishing both the pharmacokinetics and uptake of a particular therapeutic agent, as well as the pharmacodynamic vascular perturbation caused by the VDA.…”

Section: Imaging Technologiesmentioning

confidence: 99%

Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors

et al. 2021

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Tumor vasculature proliferates rapidly, generally lacks pericyte coverage, and is uniquely fragile making it an attractive therapeutic target. A subset of small-molecule tubulin binding agents cause disaggregation of the endothelial cytoskeleton leading to enhanced vascular permeability generating increased interstitial pressure. The resulting vascular collapse and ischemia cause downstream hypoxia, ultimately leading to cell death and necrosis. Thus, local damage generates massive amplification and tumor destruction. The tumor vasculature is readily accessed and potentially a common target irrespective of disease site in the body. Development of a therapeutic approach and particularly next generation agents benefits from effective non-invasive assays. Imaging technologies offer varying degrees of sophistication and ease of implementation. This review considers technological strengths and weaknesses with examples from our own laboratory. Methods reveal vascular extent and patency, as well as insights into tissue viability, proliferation and necrosis. Spatiotemporal resolution ranges from cellular microscopy to single slice tomography and full three-dimensional views of whole tumors and measurements can be sufficiently rapid to reveal acute changes or long-term outcomes. Since imaging is non-invasive, each tumor may serve as its own control making investigations particularly efficient and rigorous. The concept of tumor vascular disruption was proposed over 30 years ago and it remains an active area of research.

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Section: Imaging Technologiesmentioning

confidence: 99%

Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors

et al. 2021

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“…A wealth of experimental animal studies demonstrate the role of the serotonin systems in memory and its dysfunctions, even if their role is still poorly understood (Meneses et al, 2011; Meneses, 2013; Gasbarri and Pompili, 2014; Gasbarri et al, 2016; Meneses and Gasbarri, 2016). It is beyond the scope of this paper to describe the results of all these studies (for an in-depth analysis please refer to Meneses et al, 2011; Roberts and Hedlund, 2012; Meneses, 2013; Glikmann-Johnston et al, 2015; Meneses and Gasbarri, 2016).…”

Section: The Role Of 5-ht In Working Spatial and Episodic Memorymentioning

confidence: 99%

“…It is beyond the scope of this paper to describe the results of all these studies (for an in-depth analysis please refer to Meneses et al, 2011; Roberts and Hedlund, 2012; Meneses, 2013; Glikmann-Johnston et al, 2015; Meneses and Gasbarri, 2016). In this context, we will focus only on the studies more relevant to our discussion.…”

Section: The Role Of 5-ht In Working Spatial and Episodic Memorymentioning

confidence: 99%

Neurobiology of Anorexia Nervosa: Serotonin Dysfunctions Link Self-Starvation with Body Image Disturbances through an Impaired Body Memory

Riva

2016

Front. Hum. Neurosci.

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The etiology of anorexia nervosa (AN) is still unclear, despite that it is a critical and potentially mortal illness. A recent neurobiological model considers AN as the outcome of dysfunctions in the neuronal processes related to appetite and emotionality (Kaye et al., 2009, 2013). However, this model still is not able to answer a critical question: What is behind body image disturbances (BIDs) in AN? The article starts its analysis from reviewing some of the studies exploring the effects of the serotonin systems in memory (episodic, working, and spatial) and its dysfunctions. The review suggests that serotonin disturbances may: (a) facilitate the encoding of third person (allocentric) episodic memories; (b) facilitate the consolidation of emotional episodic memories (e.g., teasing), if preceded by repeated stress; (c) reduce voluntary inhibition of mnestic contents; (d) impair allocentric spatial memory. If we discuss these results within the interpretative frame suggested by the “Allocentric Lock Hypothesis” (Riva, 2012, 2014), we can hypothesize that altered serotoninergic activity in AN patients: (i) improves their ability to store and consolidate negative autobiographical memories, including those of their body, in allocentric perspective; (ii) impairs their ability to trigger voluntary inhibition of the previously stored negative memory of the body; (iii) impairs their capacity to retrieve/update allocentric information. Taken together, these points suggest a possible link between serotonin dysfunctions, memory impairments and BIDs: the impossibility of updating a disturbed body memory using real time experiential data—I'm locked to a wrong body stored in long term memory—pushes AN patients to control body weight and shape even when underweight.

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“…Due to their ubiquitous nature, understanding ERK1/2 regulation is key to identifying how ERK1/2 signaling induces varying, and even contradictory, responses to particular signals [44]. To date, several modes of regulation have been identified, including the activating dual phosphorylation on the TEY motif of the activation loop by MEK [37], interactions with anchoring proteins and scaffolds which regulate substrate/enzyme colocalization and modulate activity [33, 41, 55], control over localization via phosphorylation on the SPS motif [56], crosstalk with other signaling cascades [44], and modulation of signal duration as controlled by phosphatases [57–59]. This current work identifies an additional layer of regulation through the post-translational modification of cysteine oxidation, which we demonstrate to be a modification on ERK1 and ERK2 proteins that is not restricted to a particular class of receptors or cell types.…”

Section: Discussionmentioning

confidence: 99%

Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals

Keyes

Parsonage

Yammani

et al. 2017

Free Radical Biology and Medicine

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ERK-dependent signaling is key to many pathways through which extracellular signals are transduced into cell-fate decisions. One conundrum is the way in which disparate signals induce specific responses through a common, ERK-dependent kinase cascade. While studies have revealed intricate ways of controlling ERK signaling through spatiotemporal localization and phosphorylation dynamics, additional modes of ERK regulation undoubtedly remain to be discovered. We hypothesized that fine-tuning of ERK signaling could occur by cysteine oxidation. We report that ERK is actively and directly oxidized by signal-generated H2O2 during proliferative signaling, and that ERK oxidation occurs downstream of a variety of receptor classes tested in four cell lines. Furthermore, within the tested cell lines and proliferative signals, we observed that both activation loop-phosphorylated and non-phosphorylated ERK undergo sulfenylation in cells and that dynamics of ERK sulfenylation is dependent on the cell growth conditions prior to stimulation. We also tested the effect of endogenous ERK oxidation on kinase activity and report that phosphotransfer reactions are reversibly inhibited by oxidation by as much as 80 to 90%, underscoring the importance of considering this additional modification when assessing ERK activation in response to extracellular signals.

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Editorial: Serotonin and Memory

Cited by 3 publications

References 11 publications

Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors

Non-Invasive Evaluation of Acute Effects of Tubulin Binding Agents: A Review of Imaging Vascular Disruption in Tumors

Neurobiology of Anorexia Nervosa: Serotonin Dysfunctions Link Self-Starvation with Body Image Disturbances through an Impaired Body Memory

Endogenous, regulatory cysteine sulfenylation of ERK kinases in response to proliferative signals

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