Editorial: Sleep disturbances in Parkinson's disease

Salsone, Maria; Ferini‐Strambi, Luigi

doi:10.3389/fnins.2023.1133296

Cited by 1 publication

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have shown that patients with PD with EDS showed extensive cortical and subcortical changes, such as frontal lobe atrophy, combined cortical hypoperfusion, and decreased dopamine uptake by the dopamine transporter (DAT) in the caudate nucleus, and abnormal neural activity in patients with PD with EDS and PD without EDS, the abnormality of low frequency fluctuation amplitude (ALFF) at the local level in the pons and frontal lobe, the decrease of ALFF in cingulate cortex, and the reduction of functional connection at cingulate cortex and precuneus network level [ 26 ]. In the pathogenesis of PD, apoptosis is an important reason for the loss of dopaminergic neurons, resulting in a decrease in uptake by DAT.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of plasma SIRT1 levels and whole-brain gray matter volume in Parkinson’s disease patients with cognitive impairment

Li,

Yang,

et al. 2023

Neurol Sci

View full text Add to dashboard Cite

Objective This study was designed to investigate the diagnostic value of plasma SIRT1 levels and whole-brain gray matter (GM) volume in Parkinson’s disease (PD) patients with cognitive impairment. Methods Automated enzymatic analysis was performed to measure plasma SIRT1 levels in 80 healthy controls and 77 PD patients. Motor symptoms and nonmotor symptoms in PD patients were assessed using the corresponding scales. A Siemens MAGNETOM Prisma 3 T MRI scanner was used to acquire images in 35 of 77 PD patients. Results Plasma SIRT1 levels in PD patients were lower than those in healthy controls. Plasma SIRT1 levels were negatively correlated with the age, Unified Parkinson’s Disease Rating Scale Part III (UPDRS-III) scores, anxiety, depression, excessive daytime sleepiness (EDS), quality of life, and especially cognitive impairment. Thus, it showed that plasma SIRT1 levels were relevant to visuospatial/executive function, memory, and language. Receiver-operating characteristic (ROC) analysis confirmed that plasma SIRT1 levels had good diagnostic accuracy for PD with anxiety and EDS. Furthermore, plasma SIRT1 levels had a significant positive correlation with GM volume in the whole brain, and ROC analysis confirmed that plasma SIRT1 levels and the total GM volume had good diagnostic accuracy for PD with cognitive impairment. Conclusions This study showed that plasma SIRT1 levels were correlated with the nonmotor symptoms of anxiety, depression, EDS, and especially cognitive impairment as well as the total GM volume. Furthermore, the combination of plasma SIRT1 levels and the total GM volume had good diagnostic accuracy for PD with cognitive impairment.

show abstract

Section: Discussionmentioning

confidence: 99%