Editorial: Some Speculations on the Myeloproliferative Syndromes

Dameshek, William

doi:10.1182/blood.v6.4.372.372

Cited by 986 publications

(239 citation statements)

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“…In nine of the 23 patients there was a tendency to spontaneous venous thrombosis. Arterial thrombosis affecting the blood supply to the toes was described by Epstein and Goedel (1934) and was also seen in our Case 2.…”

Section: British Journal Of Haematologysupporting

confidence: 68%

Haemorrhagic Thrombocythaemia: a Clinical and Laboratory Study

Hardisty

Wolff

1955

Br J Haematol

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Section: British Journal Of Haematologysupporting

confidence: 68%

Haemorrhagic Thrombocythaemia: a Clinical and Laboratory Study

Hardisty

Wolff

1955

Br J Haematol

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“…. "[age 3 The marrow was still crowded with cells, and fat cells were still few, but sometimes they became more numerous. The shift from segmented granulocytes to myelocytes was more pronounced.…”

Section: Chronic Myelocytic Leukemiamentioning

confidence: 99%

Chronic myelocytic leukemia versus idiopathic myelofibrosis.A diagnostic problem in bone marrow biopsies

Buyssens

Bourgeois

1977

Cancer

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Repeated bone marrow biopsies of 12 patients with chronic myelocytic leukemia (CML) and 13 patients with idiopathic myelofibrosis (IMF) were compared. The amount of cellularity, the composition of the cell population, and the stromal changes were assessed. Both diseases were divided into four stages, each with a consistent morphologic pattern. In CML, Stage 1 presented a tremendous increase in granulocytes and a drop of the erythroid series; Stage 2 showed a shift to myelocytes and a moderate increase of blasts; in Stage 3 there was a strong increase of blasts and the reappearance of red cells; and in Stage 4 hematopoietic cells disappeared with metastases of abnormal blasts to many organs. The stroma showed a progressive fibrosis so that by Stage 4 there was a totally fibrotic marrow. With IMF, Stage 1 presented a dysharmonic trilinear proliferation; in Stage 2 there was a maximum of cellularity, which remained trilinear; in Stage 3 there was a decrease of hematopoietic cells; and in Stage 4 these cells disappeared, but hematopoietic cells in dilated sinusoids of the empty marrow became apparent. The stroma showed a progressive fibrosis, ending by Stage 4 in a totally fibrotic marrow indistinguishable from the similar stage of CML. Careful analysis of the bone marrow biopsy findings permitted the stage of the disease and hence the prognosis to be determined; Stage 3 for CML means death within a short period of time. In clinically “acute” myelocytic leukemia, the biopsy helps to make the distinction between Stage 3 of an unsuspected CML and acute myelocytic leukemia.

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“…In 1951, Dameshek grouped four clinically and pathophysiologically related diseases and collectively termed them the myeloproliferative disorders (MPDs) [1]. This group includes chronic myelogenous leukemia (CML), polycythemia rubra vera (PV), essential thrombocythemia (ET) as well as agnogenic myeloid metaplasia (AMM), also known as idiopathic myelofibrosis.…”

Section: T H E M Y E L O P R O L I F E R a T I V E D I S O R D E R Smentioning

confidence: 99%

Towards a molecular understanding of polycythemia rubra vera

Pahl

2000

European Journal of Biochemistry

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Polycythemia rubra vera (PV) is one of four diseases collectively called the myeloproliferative disorders (MPDs). Each disorder leads to an increased production of one or several hematopoietic cell lineages. MPDs arise from acquired mutations in a pluripotent hematopoietic stem cell. However, the molecular mechanisms leading to the development of these diseases are poorly understood. This review will summarize and evaluate recent advances in our understanding of one particular MPD, PV.

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Editorial: Some Speculations on the Myeloproliferative Syndromes

Cited by 986 publications

References 0 publications

Haemorrhagic Thrombocythaemia: a Clinical and Laboratory Study

Haemorrhagic Thrombocythaemia: a Clinical and Laboratory Study

Chronic myelocytic leukemia versus idiopathic myelofibrosis.A diagnostic problem in bone marrow biopsies

Towards a molecular understanding of polycythemia rubra vera

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