Editorial: Special Issue on Immunohistochemical Biomarkers in Endocrine Pathology

Erickson, Lori A.; Mete, Özgür

doi:10.1007/s12022-018-9535-6

Cited by 1 publication

(2 citation statements)

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“…1c), PAX8 (Fig. 1d), and keratins [2,3]. Thyroid C cells comprise 0.1% of the glandular mass of the thyroid and produce calcitonin; they are located predominantly at the junction between the upper one-third and middle third of the lateral lobes of the thyroid but may be difficult to identify on histologic sections.…”

Section: Thyroidmentioning

confidence: 99%

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The Spectrum of Endocrine Pathology

2023

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Endocrine pathology comprises a spectrum of disorders originating in various sites throughout the body. Some disorders affect endocrine glands, and others arise from endocrine cells that are dispersed in non-endocrine tissues. Endocrine cells can broadly be classified as neuroendocrine, steroidogenic, or thyroid follicular cells; these three families have distinct embryologic origins, morphologic structure, and biochemical hormone synthetic pathways. Lesions affecting the endocrine system include developmental abnormalities, inflammatory processes that can be infectious or autoimmune, hypofunction with atrophy or hyperfunction caused by hyperplasia secondary to pathology in other sites, and neoplasia of many types. Understanding endocrine pathology requires knowledge of both structure and function, including the biochemical signaling pathways that regulate hormone synthesis and secretion. Molecular genetics has clarified sporadic and hereditary disease that is common in this field.

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Section: Thyroidmentioning

confidence: 99%

“…C cells express TTF1, calcitonin, chromogranin A, synaptophysin (inset in Fig. 1c), CEA, and keratins, while staining for PAX8 is dependent on the antibody utilized (monoclonal PAX8 antibodies are generally negative) [2,4].…”

Section: Thyroidmentioning

confidence: 99%