Editorial: Stress Induced Neural Changes in Emotional Disorders

Wang, Fushun; Pan, Fang; Tang, Yi‐Yuan; Huang, Jason H.

doi:10.3389/fpsyt.2021.710691

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…The level of p-SMAD2/3 and NEDD9 protein and the increase of the number of DCX-, MAP2- and NeuN positive cells in the hippocampus indicate that scutellaria baicalensis can mediate TGFβ3-Smad2/3-Nedd9 signal pathway protects neurons to improve depressive behavior. Jing et al ( 44 ) treated PMD model rats with electroacupuncture therapy of “combination of kidney and brain” for 28 days. Compared with clomipramine hydrochloride drug group, in the experimental group, the content of estradiol and dopamine increased, the expression of DKK-1 increased, the expression of LRP-5 and LRP-6 decreased in the hippocampus, and Wnt β- Catenin signal pathway is inhibited, thus promoting the repair of nerve cells and improving the symptoms of depression, but acupuncture has less side effects than drugs.…”

Section: Prevalent Mechanisms Of Perimenopausal Depressionmentioning

confidence: 99%

Neuroendocrine pathogenesis of perimenopausal depression

Qian

et al. 2023

Front. Psychiatry

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With the development of social economics and the increase of working pressure, more and more women are suffering from long-term serious stress and showing symptoms of perimenopausal depression (PMD). The incidence rate of PMD is increasing, and the physical and mental health are seriously affected. However, due to the lack of accurate knowledge of pathophysiology, its diagnosis and treatment cannot be accurately executed. By consulting the relevant literature in recent years, this paper elaborates the neuroendocrine mechanism of perimenopausal depression from the aspects of epigenetic changes, monoamine neurotransmitter and receptor hypothesis, glial cell-induced neuroinflammation, estrogen receptor, interaction between HPA axis and HPG axis, and micro-organism-brain gut axis. The purpose is to probe into new ways of treatment of PMD by providing new knowledge about the neuroendocrine mechanism and treatment of PMD.

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Section: Prevalent Mechanisms Of Perimenopausal Depressionmentioning

confidence: 99%

Neuroendocrine pathogenesis of perimenopausal depression

Qian

et al. 2023

Front. Psychiatry

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“…The relationship between mood disorders and CS is bidirectional. [ 26 , 27 ] Numerous studies have shown that chronic stressors can induce mood disorders in laboratory animals and increase the incidence of mood disorders in humans. [ 28 29 30 31 ] However, it is unlear whether CS is a cause or consequence of glioma development and progression.…”

Section: Introductionmentioning

confidence: 99%

Chronic stress as an emerging risk factor for the development and progression of glioma

Yi,

Lin,

She

et al. 2024

Chinese Medical Journal

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Gliomas tend to have a poor prognosis and are the most common primary malignant tumors of the central nervous system. Compared with patients with other cancers, glioma patients often suffer from increased levels of psychological stress, such as anxiety and fear. Chronic stress (CS) is thought to impact glioma profoundly. However, because of the complex mechanisms underlying CS and variability in individual tolerance, the role of CS in glioma remains unclear. This review suggests a new proposal to redivide the stress system into two parts. Neuronal activity is dominant upstream. Stress-signaling molecules produced by the neuroendocrine system are dominant downstream. We discuss the underlying molecular mechanisms by which CS impacts glioma. Potential pharmacological treatments are also summarized from the therapeutic perspective of CS.

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“…Research has shown that excessive stress exposure, failure of stress reduction mechanisms, chronic stress exposure, or exposure during sensitive periods are associated with compensatory overload and maladaptive responses that lead to many neuropsychiatric disorders [ 6 , 7 , 8 ]. Stress is therefore an important risk factor influencing the pathophysiological processes of mental disorders [ 9 ], especially depressive and anxiety disorders.…”

Section: Introductionmentioning

confidence: 99%

DNA Methylation Patterns in Relation to Acute Severity and Duration of Anxiety and Depression

Vidovič,

Pelikan,

Atanasova

et al. 2023

CIMB

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Depression and anxiety are common mental disorders that often occur together. Stress is an important risk factor for both disorders, affecting pathophysiological processes through epigenetic changes that mediate gene–environment interactions. In this study, we explored two proposed models about the dynamic nature of DNA methylation in anxiety and depression: a stable change, in which DNA methylation accumulates over time as a function of the duration of clinical symptoms of anxiety and depression, or a flexible change, in which DNA methylation correlates with the acute severity of clinical symptoms. Symptom severity was assessed using clinical questionnaires for anxiety and depression (BDI-II, IDS-C, and HAM-A), and the current episode and the total lifetime symptom duration was obtained from patients’ medical records. Peripheral blood DNA methylation levels were determined for the BDNF, COMT, and SLC6A4 genes. We found a significant negative correlation between COMT_1 amplicon methylation and acute symptom scores, with BDI-II (R(22) = 0.190, p = 0.033), IDS-C (R(22) = 0.199, p = 0.029), and HAM-A (R(22) = 0.231, p = 0.018) all showing a similar degree of correlation. Our results suggest that DNA methylation follows flexible dynamics, with methylation levels closely associated with acute clinical presentation rather than with the duration of anxiety and depression. These results provide important insights into the dynamic nature of DNA methylation in anxiety and affective disorders and contribute to our understanding of the complex interplay between stress, epigenetics, and individual phenotype.

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Editorial: Stress Induced Neural Changes in Emotional Disorders

Cited by 4 publications

References 6 publications

Neuroendocrine pathogenesis of perimenopausal depression

Neuroendocrine pathogenesis of perimenopausal depression

Chronic stress as an emerging risk factor for the development and progression of glioma

DNA Methylation Patterns in Relation to Acute Severity and Duration of Anxiety and Depression

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