Editorial: The impact of adipose tissue dysfunction on cardiovascular and renal disease, Volume II

Abstract

Editorial on the Research TopicThe impact of adipose tissue dysfunction on cardiovascular and renal disease, Volume II Obesity is a global health problem that affects millions of people and increases the risk of various chronic diseases, such as cardiovascular disease (CVD) and chronic kidney disease (CKD). Adipose tissue is a heterogeneous tissue that regulates metabolism, inflammation and immunity. It also mediates the harmful effects of obesity on health. The location and characteristics of adipose tissue determine its positive or negative impact on different organs and systems (1). Excess adipose tissue mass has been traditionally associated with metabolic dysfunction, but recent evidence suggests that adipose tissue quality and distribution are more critical for metabolic health than quantity (2). In addition to the well-known visceral and subcutaneous fat depots, other adipose tissues around blood vessels, such as perivascular, perirenal and epicardial fat, have emerged as novel contributors to CVD and CKD pathogenesis (3-5). These adipose tissues have unique features and dysfunctions in obesity and metabolic syndrome that may cause vascular and renal damage. However, the molecular mechanisms that mediate the communication between these adipose tissues and the cardiovascular and renal systems are still unclear and need further research. This Research Topic showcases a collection of 7 original research and 4 review articles that span from basic to clinical research, providing new insights into the pathophysiology of adipose dysfunction in CVD and CKD.Obesity predisposes to various comorbidities. However, the risk of developing these comorbidities differs among obese individuals, depending on fat distribution in different body regions. Liu et al. examined the role of central fat distribution and comorbidity in 4899 obese participants from the NHANES database. They found that more than half had at least one comorbidity, and that central fat distribution varied by sex and age. They also Frontiers in Endocrinology frontiersin.org 01