Editorial: The impact of genetics on CRC therapy: from adaptive mutability to drug resistance

Crisafulli, Giovanni; Siravegna, Giulia

doi:10.3389/fonc.2023.1260158

Front. Oncol.

2023

DOI: 10.3389/fonc.2023.1260158

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Editorial: The impact of genetics on CRC therapy: from adaptive mutability to drug resistance

Giovanni Crisafulli

Giulia Siravegna²

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2024

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A perspective on tumor radiation resistance following high-LET radiation treatment

Rajpurohit,

Sharma,

Lal

et al. 2024

J Cancer Res Clin Oncol

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High-linear energy transfer (LET) radiation is a promising alternative to conventional low-LET radiation for therapeutic gain against cancer owing to its ability to induce complex and clustered DNA lesions. However, the development of radiation resistance poses a significant barrier. The potential molecular mechanisms that could confer resistance development are translesion synthesis (TLS), replication gap suppression (RGS) mechanisms, autophagy, epithelial-mesenchymal transition (EMT) activation, release of exosomes, and epigenetic changes. This article will discuss various types of complex clustered DNA damage, their repair mechanisms, mutagenic potential, and the development of radiation resistance strategies. Furthermore, it highlights the importance of careful consideration and patient selection when employing high-LET radiotherapy in clinical settings.

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A perspective on tumor radiation resistance following high-LET radiation treatment

Rajpurohit,

Sharma,

Lal

et al. 2024

J Cancer Res Clin Oncol

View full text Add to dashboard Cite

show abstract

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Editorial: The impact of genetics on CRC therapy: from adaptive mutability to drug resistance

Cited by 1 publication

References 30 publications

A perspective on tumor radiation resistance following high-LET radiation treatment

A perspective on tumor radiation resistance following high-LET radiation treatment

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