Editorial: the increasing burden of microscopic colitis

Guagnozzi, Danila; Tontini, Gian Eugenio; Pastorelli, Luca

doi:10.1111/apt.15363

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“…Patients report chronic, watery, non-bloody diarrhea, abdominal pain, weight loss, and fatigue that may impair health-related quality of life (1). Over the last few years, the incidence and prevalence of this condition has risen, partly due to both greater awareness and increasing numbers of patients being diagnosed (2)(3)(4)(5). Diagnosis of MC is by colonoscopy, and histological analysis of multiple biopsy specimens collected along the colon is used to assess activity (6,7).…”

Section: Editorial On the Research Topicmentioning

confidence: 99%

Editorial: The Dark Side of Microscopic Colitis

Pisani

Tontini

Pastorelli³

2021

Front. Med.

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Section: Editorial On the Research Topicmentioning

confidence: 99%

Editorial: The Dark Side of Microscopic Colitis

Pisani

Tontini

Pastorelli³

2021

Front. Med.

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Low prevalence of colorectal neoplasia in microscopic colitis: A large prospective multi-center study

Borsotti

Barberio

D’Incà

et al. 2021

Digestive and Liver Disease

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Microscopic Colitis: A Challenging Disorder

Tulassay

Mihály

Herszényi

2019

Dig Dis

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Background: The clinical importance of microscopic colitis (MC) is increasing. This is explained by both the increasing incidence and the challenges posed by the disease. However, recent MC data also reveal a number of doubts and uncertainties. Summary: This review focuses on current knowledge of MC and highlights the various controversies and criticisms regarding the clinical data about definitions, subtypes, pathogenesis, diagnosis, and treatment of this condition. Key Messages: The diagnosis of MC is based on histology, which distinguishes 2 subtypes. However, transitional forms often cause misclassification, which calls into question the reality (specificity, meaning) of the distinction between the 2 forms. The location of the colon biopsy is not defined by international consensus. There is no credible, clear explanation for the incidence increase. The pathogenesis is unknown, probably multifactorial, but the importance of the immunological background is increasing. The natural history of the disease and the underlying cause of relapses are unclear. It is suggested that MC would be the prelude of IBD. Further data collection is needed to clarify these issues.

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Editorial: the increasing burden of microscopic colitis

Abstract: Linked ContentThis article is linked to Fernandez‐Bañares et al paper. To view this article, visit https://doi.org/10.1111/apt.13477.

Cited by 3 publications

References 10 publications

Editorial: The Dark Side of Microscopic Colitis

Editorial: The Dark Side of Microscopic Colitis

Low prevalence of colorectal neoplasia in microscopic colitis: A large prospective multi-center study

Microscopic Colitis: A Challenging Disorder

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