Editorial: The treatment of multi‐drug resistant tuberculosis – a return to the pre‐antibiotic era?

Ollé-Goig, Jaime E

doi:10.1111/j.1365-3156.2006.01770.x

Cited by 4 publications

(2 citation statements)

References 22 publications

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“…Several reports have shown that MDR strains are transmitted effectively from person to person [ 1 ]. 55% of patients from the South African cohort had no previous treatment.…”

Section: Discussionmentioning

confidence: 99%

“…The emergence of multi drug resistance, defined as resistance to at least rifampin (RMP) and isoniazid (INH) is of great concern. Recently, reports of strains with extensively drug resistant (XDR) TB have been described and the question was raised, whether we enter the post-antibiotic era [ 1 - 4 ]. In October 2006 the WHO Global Task Force on XDR-TB met in Geneva, Switzerland, and approved the following revised laboratory case definition of XDR-TB: "TB showing resistance to at least rifampin and isoniazid, which is the definition of multi drug resistant (MDR) TB, in addition to any fluoroquinolone, and to at least 1 of the 3 following injectable drugs used in anti-TB treatment: capreomycin, kanamycin and amikacin" [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Extensively drug resistant tuberculosis in a high income country: A report of four unrelated cases

Blaas

Mütterlein²,

Weig

et al. 2008

BMC Infect Dis

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“…Several reports have shown that MDR strains are transmitted effectively from person to person [ 1 ]. 55% of patients from the South African cohort had no previous treatment.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extensively drug resistant tuberculosis in a high income country: A report of four unrelated cases

Blaas

Mütterlein²,

Weig

et al. 2008

BMC Infect Dis

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Structure‐Based Design on the Way to New Anti‐Infectives

Hirsch

2010

Ideas in Chemistry and Molecular Sciences

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Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase IspE of the Non‐Mevalonate Pathway for Isoprenoid Biosynthesis

et al. 2008

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The enzymes of the non-mevalonate pathway for isoprenoid biosynthesis are attractive targets for the development of novel drugs against malaria and tuberculosis. This pathway is used exclusively by the corresponding pathogens, but not by humans. A series of water-soluble, cytidine-based inhibitors that were originally designed for the fourth enzyme in the pathway, IspD, were shown to inhibit the subsequent enzyme, the kinase IspE (from Escherichia coli). The binding mode of the inhibitors was verified by co-crystal structure analysis, using Aquifex aeolicus IspE. The crystal structures represent the first reported example of a co-crystal structure of IspE with a synthetic ligand and confirmed that ligand binding affinity originates mainly from the interactions of the nucleobase moiety in the cytidine binding pocket of the enzyme. In contrast, the appended benzimidazole moieties of the ligands adopt various orientations in the active site and establish only poor intermolecular contacts with the protein. Defined binding sites for sulfate ions and glycerol molecules, components in the crystallization buffer, near the well-conserved ATP-binding Gly-rich loop of IspE were observed. The crystal structures of A. aeolicus IspE nicely complement the one from E. coli IspE for use in structure-based design, namely by providing invaluable structural information for the design of inhibitors targeting IspE from Mycobacterium tuberculosis and Plasmodium falciparum. Similar to the enzymes from these pathogens, A. aeolicus IspE directs the OH group of a tyrosine residue into a pocket in the active site. In the E. coli enzyme, on the other hand, this pocket is lined by phenylalanine and has a more pronounced hydrophobic character.

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Editorial: The treatment of multi‐drug resistant tuberculosis – a return to the pre‐antibiotic era?

Cited by 4 publications

References 22 publications

Extensively drug resistant tuberculosis in a high income country: A report of four unrelated cases

Extensively drug resistant tuberculosis in a high income country: A report of four unrelated cases

Structure‐Based Design on the Way to New Anti‐Infectives

Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase IspE of the Non‐Mevalonate Pathway for Isoprenoid Biosynthesis

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