EDITORIAL (Thematic Issue: Brain Gut Axis-New View)

Sikirić, Predrag

doi:10.2174/1570159x1408161031125729

Cited by 2 publications

(2 citation statements)

References 12 publications

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“…[ 17 ] Brain-gut peptide refers to a type of small molecular peptide with double distribution in gastrointestinal tract and brain, being critical to gastrointestinal motility. [ 18 ] Peripheral ghrelin has been suggested to be vital to regulate gastrointestinal function, while ghrelin in central nervous system can considerably affect gastrointestinal activity. [ 19 ] An experiment also suggested that electroacupuncture can reduce auxin and neuropeptide Y in rats and reduce their food intake.…”

Section: Introductionmentioning

confidence: 99%

Effect of acupuncture on hormone level in patients with gastrointestinal dysfunction after general anesthesia

Yuan

Yang

et al. 2020

Medicine

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Background: Postoperative gastrointestinal dysfunction (PGD) refers to one of the common postoperative complications. Acupuncture can facilitate the recovery of PGD, whereas no therapeutic schedule of acupuncture has been internationally recognized for treating PGD. In the present study, a scientific trial protocol has been proposed to verify the feasibility of acupuncture in treating gastrointestinal dysfunction after laparoscopic cholecystectomy under general anesthesia. We conduct this protocol to investigate whether acupuncture recovery gastrointestinal dysfunction by influencing the expression of gastrointestinal hormone. Method: The present study refers to a randomized, evaluator blinded, controlled, multi-center clinical trial; it was designed complying with the Consolidated Standards of Reporting Trials (CONSORT 2010) as well as the Standard for Reporting Interventions in Controlled Trials of Acupuncture (STRICTA). The subjects will be taken from the inpatients having undergone laparoscopic surgery of Mianyang Affiliated Hospital of Chengdu University of traditional Chinese medicine, Mianyang Third Hospital and Mianyang Anzhou Hospital. Based on the random number yielded using SPSS 25.0 software, the qualified subjects will be randomly classified to the experimental group and the control group. Therapies will be performed 30 min once after operation, the experimental group will be treated with acupuncture, while the control group will receive intravenous injection of granisetron. The major outcome will be the time to first flatus, and the secondary outcomes will include the time to first defecation, abdominal pain, dosage of analgesia pump, abdominal distention, nausea, vomiting, gastrointestinal hormone, as well as mental state. The efficacy and safety of acupuncture will be also assessed following the principle of Good Clinical Practice (GCP). Discuss: A standardized and scientific clinical trial is conducted to assess the efficacy and safety of acupuncture for gastrointestinal dysfunction after laparoscopic cholecystectomy under general anesthesia. The aim is to objectively evidence and improves the clinical practice of acupoint prescription, as an attempt to promote the clinical application of this technology.

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Section: Introductionmentioning

confidence: 99%

Effect of acupuncture on hormone level in patients with gastrointestinal dysfunction after general anesthesia

Yuan

Yang

et al. 2020

Medicine

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“…Signals from the brain can affect gastrointestinal motility, whereas information from the Gastrointestinal tract can also affect brain function. Brain-gut peptide is a kind of small molecular peptide with double distribution in gastrointestinal tract and brain, which play an important role in gastrointestinal motility [15] . It has been shown that peripheral ghrelinis is critical in regulating gastrointestinal function, while ghrelin in central nervous system can affect gastrointestinal activity [16] .…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of Acupuncture for Gastrointestinal Dysfunction after Laparoscopy: study protocol for a randomized controlled trial

Liu¹,

Yuan²,

Q³

et al. 2019

Preprint

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Background: Postoperative gastrointestinal dysfunction is one of the common complications after surgery. At present, there has no internationally recognized acupuncture program although it has a positive effect on the recovery of postoperative gastrointestinal function. In this report, we have designed a scientific trial protocol to analyze the feasibility of applying acupuncture to gastrointestinal dysfunction after laparoscopic surgery. We intend to conduct a randomized controlled trial based on this protocol to evaluate the efficacy and safety of the acupuncture for postoperative gastrointestinal dysfunction. Method / design: This study is a randomized, evaluator blinded, controlled, multi-center clinical trial, which has been designed according to the Consolidated Standards of Reporting Trials (CONSORT 2010) and the standard for Reporting Interventions in Controlled Trials of Acupuncture (STRICTA). The subjects will be chosen from the inpatients who have undergone laparoscopic surgery of Mianyang Hospital Affiliated to Chengdu University of traditional Chinese medicine, Mianyang Third People's Hospital and Mianyang Anzhou District People's Hospital. According to the random number generated by SPSS 25.0 software, the qualified subjects will be randomly assigned to the experimental group, the control group, and the blank group. Therapies will be performed 30 minutes after operation, the experimental group will be treated with acupuncture, the control group will be treated with intravenous injection of granisetron, and the blank group will be treated with intravenous injection of physiological saline. The main outcome is the first time of flatus after operation, and the secondary outcomes are abdominal pain, abdominal distention, nausea, vomiting times, gastrointestinal hormone level, and mental state. We will also evaluate the efficacy and safety of acupuncture on the basis of the principle of good clinical practice (GCP). Discuss: This is a standardized and scientific clinical trial to evaluate the efficacy and safety of acupuncture for gastrointestinal dysfunction after laparoscopic surgery. Our goal is to provide objective evidence and improve the acupoint prescription in clinical practice, so as to promote the clinical application of this technology. Trial registration China clinical trial registration ID: CHICTR -1800016991. Registered on 6 July 2018.Discussion

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EDITORIAL (Thematic Issue: Brain Gut Axis-New View)

Cited by 2 publications

References 12 publications

Effect of acupuncture on hormone level in patients with gastrointestinal dysfunction after general anesthesia

Effect of acupuncture on hormone level in patients with gastrointestinal dysfunction after general anesthesia

Efficacy and safety of Acupuncture for Gastrointestinal Dysfunction after Laparoscopy: study protocol for a randomized controlled trial

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