Editorial: Traditional Chinese Medicine: Organ Vascular Injury - Volume II

Han, Jing‐Yan; Meininger, Gerald A.; Luo, Jincai; Huang, Qiaobing

doi:10.3389/fphys.2021.677858

Cited by 3 publications

(4 citation statements)

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“…In addition, in vitro studies also indicated that it could promote the secretion of brain-derived neurotrophic and ciliary neurotrophic factors, thus regulating the sphingolipid and neurotrophic signaling pathways . Other potential mechanisms, including anti-inflammation, antiapoptosis, and proangiogenesis, have also been reported …”

Section: Discussionmentioning

confidence: 96%

“… 9 Other potential mechanisms, including anti-inflammation, antiapoptosis, and proangiogenesis, have also been reported. 9 , 11 , 12 , 13 …”

Section: Discussionmentioning

confidence: 99%

“…It has been widely used in the treatment of ischemic stroke in China . The active ingredient in GDLM has been shown to have a variety of neuroprotective and reparative effects that can help maintain the blood-brain barrier; reduce brain edema; improve energy metabolism; help with antioxidation, anti-inflammation, and antiapoptosis; and promote angiogenesis . Several clinical studies have evaluated the efficacy of GDLM in the treatment of stroke, whereas most of these studies were limited by small sample size, single-center design, and no placebo-controlled group to compare the single therapeutic response with GDLM.…”

Section: Introductionmentioning

confidence: 99%

“… 8 , 9 , 10 The active ingredient in GDLM has been shown to have a variety of neuroprotective and reparative effects that can help maintain the blood-brain barrier; reduce brain edema; improve energy metabolism; help with antioxidation, anti-inflammation, and antiapoptosis; and promote angiogenesis. 9 , 11 , 12 , 13 Several clinical studies have evaluated the efficacy of GDLM in the treatment of stroke, 11 , 14 whereas most of these studies were limited by small sample size, single-center design, and no placebo-controlled group to compare the single therapeutic response with GDLM. Therefore, it is still of great importance to verify the therapeutic value of the multitargeted GDLM therapuetic in well-designed randomized clinical trials with a sufficient numer of patients with AIS.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and Safety of Ginkgo Diterpene Lactone Meglumine in Acute Ischemic Stroke

Zhang

Wang

et al. 2023

JAMA Netw Open

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ImportanceGinkgo diterpene lactone meglumine (GDLM) has attracted much attention because of its potential neuroprotective properties in ischemic stroke. The efficacy of GDLM in patients with acute ischemic stroke (AIS) needs to be verified by well-designed randomized clinical trials.ObjectiveTo assess the efficacy and safety of GDLM in patients with AIS.Design, Setting, and ParticipantsThis multicenter, randomized, double-blind, placebo-controlled, parallel-group trial involved 3448 patients who had AIS, were aged 18 to 80 years, had a clinically diagnosed AIS symptom within 48 hours of onset, had a modified Rankin Scale (mRS) score of 0 or 1 prior to onset, and had a National Institutes of Health Stroke Scale score ranging from 4 to 24. The trial took place at 100 centers in China from February 1, 2016, to May 1, 2018. The mRS is a global stroke disability scale with scores ranging from 0 (no symptoms or completely recovered) to 6 (death). The National Institutes of Health Stroke Scale is a tool used by clinicians to quantify impairment caused by stroke (range, 0-42, with higher scores indicating greater severity). Data were analyzed from January 2019 to December 2022.InterventionsPatients were randomized to receive GDLM or placebo once daily via intravenous infusion in a 1:1 ratio. The treatment was dispensed within 48 hours after symptoms and continued for 14 days. Interventions of thrombolysis and thrombectomy were not permitted during the treatment.Main Outcomes and MeasuresThe primary outcome was the proportion of patients with an mRS of 0 or 1 on day 90 after randomization. Safety outcomes included adverse events and serious adverse events.ResultsA total of 3448 patients were randomized, with 1725 patients assigned to the GDLM group and 1723 patients assigned to the placebo group. The median (IQR) age of the patients was 63 (55-71) years, and 1232 (35.7%) were women. The primary outcome on day 90 occurred in 877 patients (50.8%) in the GDLM group, and 759 patients (44.1%) in the placebo group (risk difference, 6.79%; 95% CI, 3.46%-10.10%; odds ratio, 1.31; 95% CI, 1.15-1.50; relative risk, 1.15; 95% CI, 1.08-1.24; P &lt; .001). Adverse events occurred relatively equally between the 2 groups (303 [17.6%] vs 298 [17.3%]; risk difference, 0.27%; 95% CI, −2.26% to 2.80%; odds ratio, 1.02; 95% CI, 0.85-1.21; relative risk, 1.02; 95% CI, 0.88-1.17; P = .83).Conclusions and RelevanceAmong patients with AIS in this randomized clinical trial, GDLM improved the proportion of patients achieving favorable clinical outcomes at 90 days compared with placebo.Trial RegistrationClinicalTrials.gov Identifier: NCT02526225

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Section: Discussionmentioning

confidence: 96%

“… 9 Other potential mechanisms, including anti-inflammation, antiapoptosis, and proangiogenesis, have also been reported. 9 , 11 , 12 , 13 …”

Section: Discussionmentioning

confidence: 99%