Editorial: Translational Insights Into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma

Radermacher, Peter; Billiar, Timothy R.; Ghezzi, Pietro; Märtin, Lukas; Thiemermann, Christoph

doi:10.3389/fimmu.2020.01987

Cited by 5 publications

(5 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the number of days of fever ≥3 days is one of the influencing factors for wound infection in severe trauma patients. The reason for the analysis may be that fever is the stress‐induced inflammatory reaction of the body; prolonged fever is related to the body's continuous anti‐infective immune response 16 . Using urinary catheters increases the probability of exposure to the patient's internal environment and the risk of infection.…”

Section: Discussionmentioning

confidence: 99%

“…The reason for the analysis may be that fever is the stress‐induced inflammatory reaction of the body; prolonged fever is related to the body's continuous anti‐infective immune response. 16 Using urinary catheters increases the probability of exposure to the patient's internal environment and the risk of infection. On the contrary, patients in critical condition need to use many antibacterial drugs to control the infection empirically.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Etiological characteristics of wound infection in severe trauma patients and logistic regression analysis of influencing factors of infection

Pan,

Mo,

2024

International Wound Journal

View full text Add to dashboard Cite

To investigate the etiological characteristics of wound infection in severe trauma patients and logistic regression analysis of the influencing factors of infection. The 116 patients with severe trauma who were intervened in our hospital from 22 October 2017 to 9 September 2019 were selected as the subjects of this retrospective study and divided into a control group and an observation group according to whether they were infected or not, 58 cases each. Observe and compare the pathogenic characteristics (pathogen distribution and drug resistance) of the two groups of patients and logistic regression analysis of the influencing factors of infection. The gram‐positive bacteria in the observation group were mainly Staphylococcus aureus, accounting for 17.20%; the fungi were mainly Candida tropicalis, accounting for 17.20%; and the gram‐negative bacteria were mainly Acinetobacter baumannii, accounting for 20.39%; the control group was gram‐positive. The main bacteria are S. aureus, accounting for 8.60%; the fungi are mainly Candida albicans, accounting for 4.3%; and the gram‐negative bacteria, which are mainly Pseudomonas aeruginosa, accounting for 14.56%. Gram‐positive bacteria Enterococcus faecium, S. aureus, Enterococcus faecalis, Staphylococcus epidermidis. The highest drug resistance of other gram‐positive bacteria is penicillin and erythromycin at 85.00% and above. Fungi C. tropicalis, Candida parapsilosis, C. albicans, fluconazole and amphotericin B have the highest resistance to 80.00% and above. Gram‐negative bacteria A. baumannii, Ps. aeruginosa, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Enterobacter cloacae and other gram‐negative bacteria are the most resistant to ampicillin, and Piperacillin was 70.00% and above. The combined primary diseases of the two groups of patients, ventilator use ≧3 days, long‐term use of glucocorticoids, catheter use days ≧5 days, fever days ≧3 days and long‐term use of broad‐spectrum antimicrobial drugs, the difference is statistically significant academic significance (p < 0.05). Logistic analysis showed that combined with underlying diseases, fever days ≥3 days, long‐term use of glucocorticoids and catheter use days ≥5 days are the influencing factors for the occurrence of wound infections in patients with severe trauma. Trauma patients are prone to wound infections, and there are many influencing factors. Close observation of patients should be strengthened. Effective prevention and control measures should be taken for related influencing factors to reduce the incidence of infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Etiological characteristics of wound infection in severe trauma patients and logistic regression analysis of influencing factors of infection

Pan,

Mo,

2024

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…Despite some similarities with sepsis physiopathology, a complete translational organ dysfunction pathophysiology in trauma would be reductionism. 69 Injury mechanism, massive transfusion, TIC, TE, TBI, and systemic inflammation lead to organ injuries. 70 Tissue injury and ischemiareperfusion contribute to increasing DAMP levels and subsequent systemic inflammation in the form of PAMPs, histones, mitochondrial DNA, ATP, and other alarmins.…”

Section: Patient Patterns and Mof: Advances In Molecular Biologymentioning

confidence: 99%

“…As advances are made in salvaging patients with massive hemorrhage, there has been a shift from early mortality to later mortality, especially among in extremis patients 4 who are at high risk of MOF development. Despite some similarities with sepsis physiopathology, a complete translational organ dysfunction pathophysiology in trauma would be reductionism 69 . Injury mechanism, massive transfusion, TIC, TE, TBI, and systemic inflammation lead to organ injuries 70 .…”

Section: Organs and Immunity Failuresmentioning

confidence: 99%

Advances in trauma care to save lives from traumatic injury: A narrative review

Schmitt¹,

Gurney

Ariès

et al. 2023

J Trauma Acute Care Surg

View full text Add to dashboard Cite

Recent advances on trauma management from the prehospital setting to in hospital care led to a better surviving severe trauma rate. Mortality from exsanguination remains the first preventable mortality. Damage-control resuscitation and surgery are evolving and thus some promising concepts are developing. Transfusion toolkit is brought on the prehospital scene while temporary bridge to hemostasis may be helpful. Panel transfusion products allow an individualized ratio assumed by fresh frozen or lyophilized plasma, fresh or cold-stored whole blood, fibrinogen, four-factor prothrombin complex concentrates. Growing interest is raising in whole blood transfusion, resuscitative endovascular balloon occlusion of the aorta use, hybrid emergency room, viscoelastic hemostatic assays to improve patient outcomes. Microcirculation, traumatic endotheliopathy, organ failures and secondary immunosuppression are point out since late deaths are increasing and may deserve specific treatment. As each trauma patient follows his own course over the following days after trauma, trauma management may be seen through successive, temporal, and individualized aims.

show abstract

“…Overall, the therapeutic measures investigated all aimed to target the abovementioned underlying molecular processes of hepatic IRI. These include the reduction of reactive oxygen species by administration of free radical scavengers (e.g., N-acetyl-cysteine), the modulation of the cytokine response and blockage of immune activation (e.g., steroids, gadolinium chloride), and the preservation of organ function through ex vivo organ perfusion and ischemic preconditioning; however, many approaches have only been validated in preclinical studies, or have not been proven successful in the clinical setting underscoring the complexity of IRI [ 11 , 98 , 101 , 102 ]. The effect of immunosuppressants (azathioprine, cyclosporine A, tacrolimus, rapamycin, etc.)…”

Section: Therapeutic Approachesmentioning

confidence: 99%

Molecular Mechanisms of Ischaemia-Reperfusion Injury and Regeneration in the Liver-Shock and Surgery-Associated Changes

Pretzsch

Nieß

Khaled

et al. 2022

IJMS

View full text Add to dashboard Cite

Hepatic ischemia-reperfusion injury (IRI) represents a major challenge during liver surgery, liver preservation for transplantation, and can cause hemorrhagic shock with severe hypoxemia and trauma. The reduction of blood supply with a concomitant deficit in oxygen delivery initiates various molecular mechanisms involving the innate and adaptive immune response, alterations in gene transcription, induction of cell death programs, and changes in metabolic state and vascular function. Hepatic IRI is a major cause of morbidity and mortality, and is associated with an increased risk for tumor growth and recurrence after oncologic surgery for primary and secondary hepatobiliary malignancies. Therapeutic strategies to prevent or treat hepatic IRI have been investigated in animal models but, for the most part, have failed to provide a protective effect in a clinical setting. This review focuses on the molecular mechanisms underlying hepatic IRI and regeneration, as well as its clinical implications. A better understanding of this complex and highly dynamic process may allow for the development of innovative therapeutic approaches and optimize patient outcomes.

show abstract

Editorial: Translational Insights Into Mechanisms and Therapy of Organ Dysfunction in Sepsis and Trauma

Cited by 5 publications

References 4 publications

Etiological characteristics of wound infection in severe trauma patients and logistic regression analysis of influencing factors of infection

Etiological characteristics of wound infection in severe trauma patients and logistic regression analysis of influencing factors of infection

Advances in trauma care to save lives from traumatic injury: A narrative review

Molecular Mechanisms of Ischaemia-Reperfusion Injury and Regeneration in the Liver-Shock and Surgery-Associated Changes

Contact Info

Product

Resources

About