Editorial: Vascular smooth muscle cell fate and vascular remodeling: Mechanisms, therapeutic targets, and drugs, volume I

Wang, Qilong; Dai, Xiaohu; MacRae, Vicky; Song, Ping

doi:10.3389/fphar.2022.989689

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…However, VSMCs undergo phenotypic switching after arterial injury, becoming osteochondrocyte-like cells, foam cells, or myofibroblasts [ 8 , 9 ]. This process includes a decrease in the expression of genes related to VSMC differentiation and an increase in VSMC migration, proliferation, and the production of extracellular matrix (ECM) elements necessary for vascular repair [ 10 , 11 ], which is critical for the formation of arterial lesions and vascular remodeling [ 6 ]. Phenotypically modified VSMCs contribute to various cardiovascular diseases such as atherosclerosis, aortic aneurysm, transplant vasculopathy, intimal hyperplasia and restenosis, vascular calcification, hypertension, and aberrant tumor vasculature [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Influence of DNA Methylation on Vascular Smooth Muscle Cell Phenotypic Switching

Yorn,

Kim,

Jeong

2024

IJMS

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Vascular smooth muscle cells (VSMCs) are crucial components of the arterial wall, controlling blood flow and pressure by contracting and relaxing the artery walls. VSMCs can switch from a contractile to a synthetic state, leading to increased proliferation and migratory potential. Epigenetic pathways, including DNA methylation, play a crucial role in regulating VSMC differentiation and phenotypic flexibility. DNA methylation involves attaching a methyl group to the 5’ carbon of a cytosine base, which regulates gene expression by interacting with transcription factors. Understanding the key factors influencing VSMC plasticity may help to identify new target molecules for the development of innovative drugs to treat various vascular diseases. This review focuses on DNA methylation pathways in VSMCs, summarizing mechanisms involved in controlling vascular remodeling, which can significantly enhance our understanding of related mechanisms and provide promising therapeutic approaches for complex and multifactorial diseases.

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Section: Introductionmentioning

confidence: 99%

Influence of DNA Methylation on Vascular Smooth Muscle Cell Phenotypic Switching

Yorn,

Kim,

Jeong

2024

IJMS

View full text Add to dashboard Cite

show abstract

Editorial: Vascular smooth muscle cell fate and vascular remodeling: Mechanisms, therapeutic targets, and drugs, volume I

Abstract: Editorial on the Research Topic Vascular smooth muscle cell fate and vascular remodeling: Mechanisms, therapeutic targets, and drugs, volume I

Cited by 1 publication

References 8 publications

Influence of DNA Methylation on Vascular Smooth Muscle Cell Phenotypic Switching

Influence of DNA Methylation on Vascular Smooth Muscle Cell Phenotypic Switching

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