Editorials

Menon, P. S. N.; Gaur, Ajay; Bhattacharya, Sujit; Sur, Dipika; Mahalanabis, Dilip

doi:10.1007/s13312-012-0031-7

Cited by 1 publication

(2 citation statements)

References 7 publications

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“…A positive association of adiponectin with waist to height ratio and an inverse relationship with weight, waist circumference, and muscle mass was revealed in T1D children and adolescents in the present study. In agreement, previous studies describe an inverse relationship of adiponectin to obesity and hyperinsulinemia in pediatric populations [ 8 , 26 ].…”

Section: Discussionsupporting

confidence: 91%

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The Effect of Metabolic Profile on Leptin, Adiponectin, and hs-CRP in Children and Adolescents with Type 1 Diabetes

et al. 2022

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Adipokines are a superfamily of cell signaling proteins produced by the adipose tissue. This study’s purpose was to reveal the association of adipokines (leptin, adiponectin), hs-CRP, and IL-6 with well-known cardiovascular risk factors (lipid profile, diabetes control, obesity, physical activity) in children and adolescents with T1D. This cross-sectional study included 80 participants (36 boys) with T1D, aged (mean ± SD) 14.8 ± 3.4 years. Body Mass Index (BMI), metabolic profile, and level of physical activity were assessed (using pedometers) for evaluation of their effect on serum leptin, adiponectin, IL-6, and hs-CRP. Leptin levels were associated with BMI (beta = 0.184, p < 0.001), waist to hip ratio (beta = −2.017, p = 0.022), Low Density Lipoprotein-C (LDL-C) (beta = 0.021, p = 0.005), and fat mass (beta = 14.07, p < 0.001). Adiponectin was correlated with waist to height ratio (beta = 0.048, p = 0.006), ΒΜΙ (beta = −0.056, p = 0.005), and muscle mass (beta = −0.013, p = 0.020). Interestingly, hs-CRP was associated with weight (beta = 0.035, p < 0.001), ΒΜI (beta = 0.186, p < 0.001), fat mass (beta = 5.2859, p = 0.004), and muscle mass (beta = 0.027, p = 0.008). Multiple regression analysis of muscle mass unveiled associations with log hs-CRP (beta = −1.237, p = 0.014) and inverse IL−6 (beta = 18.57, p = 0.01). Finally, multiple regression models of fat mass unveiled associations with physical activity (7-day-total-step-count) (beta = −3.90 × 10−7, p = 0.027), Inverse IL-6 (beta = −0.1572, p = 0.009), and squared leptin (beta = 0.0077, p = 0.03). This study reports a positive association of leptin with LDL-C, BMI, fat mass, and hip circumference and a negative association of adiponectin with BMI and muscle mass. Finally, hs-CRP was associated with HbA1c, fat mass, and BMI. We propose that leptin, adiponectin, and hs-CRP could be used as prognostic indicators of cardiovascular risk in children with T1D.

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Section: Discussionsupporting

confidence: 91%

“…Elevated leptin levels are found in the majority of obese patients, suggesting a state of leptin resistance [ 6 , 7 ]. Adiponectin on the other hand is an adipokine usually found in low levels in obese individuals, with anti-atherogenic, anti-diabetic, and anti-inflammatory properties [ 8 ].…”

Section: Introductionmentioning

confidence: 99%